Co-infection of influenza A virus and SARS-CoV-2: A retrospective cohort study
Co-infection of influenza A virus and SARS-CoV-2: A retrospective cohort study
复制标题
DOI：
10.1002/jmv.26817
复制
发表时间：
2021-01-27
影响因子：
12.7
通讯作者：
Liu, Xinmin
中科院分区：
文献类型：
--
作者：
Cheng, Yuan;Ma, Jing;Liu, Xinmin
由严重急性呼吸系统综合征冠状病毒2型（SARS-CoV-2）引起的2019冠状病毒（COVID-19）大流行已蔓延至全球，并导致全球超过1，686，267人死亡。在即将到来的流感季节合并感染甲型流感病毒（IFV-A）可能会使COVID-19的诊断和治疗复杂化。对合并感染的流行病学和结果知之甚少。回顾性分析了2020年1月28日至2020年3月24日在武汉同济医院治疗的213名COVID-19患者的数据。97例患者（45.5%）抗IFV-A免疫球蛋白M抗体检测呈阳性。对单纯SARS-CoV-2感染和SARS-CoV-2/IFV-A混合感染患者的临床特征进行描述和分析。合并感染的患者表现出与仅感染SARS-CoV-2的患者相似的症状模式和临床结局。然而，仅在SARS-CoV-2感染患者中观察到血清细胞因子（白细胞介素-2R [IL-2 R]、IL-6、IL-8和肿瘤坏死因子-α）和心肌肌钙蛋白I的表达增加以及淋巴结病的发生率较高。SARS-CoV-2感染组的男性患者和年龄小于60岁的患者的计算机断层扫描评分也显著高于合并感染组的患者，表明IFV-A合并感染对疾病结局没有影响，但减轻了某些COVID-19患者人群的炎症。该研究将为即将到来的流感季节诊断和治疗IFV-A和SARS-CoV-2合并感染病例提供参考。
The coronavirus 2019 (COVID-19) pandemic, caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has spread across the world and is responsible for over 1,686,267 deaths worldwide. Co-infection with influenza A virus (IFV-A) during the upcoming flu season may complicate diagnosis and treatment of COVID-19. Little is known about epidemiology and outcomes of co-infection. Data for 213 COVID-19 patients treated at Tongji Hospital in Wuhan from January 28, 2020 to March 24, 2020 were retrospectively analyzed. Ninety-seven of the patients (45.5%) tested positive for anti- IFV-A immunoglobulin M antibodies. The clinical characteristics were described and analyzed for patients with SARS-CoV-2 infection only and patients with SARS-CoV-2/IFV-A co-infection. Patients with co-infection showed similar patterns of symptoms and clinical outcomes to patients with SARS-CoV-2 infection only. However, an increased expression of serum cytokines (interleukin-2R [IL-2R], IL-6, IL-8, and tumor necrosis factor-alpha) and cardiac troponin I, and higher incidence of lymphadenopathy were observed in patients with SARS-CoV-2 infection only. Male patients and patients aged less than 60 years in the SARS-CoV-2 infection group also had significantly higher computed tomography scores than patients in co-infection group, indicating that co-infection with IFV-A had no effect on the disease outcome but alleviated inflammation in certain populations of COVID-19 patients. The study will provide a reference for diagnosing and treating IFV-A and SARS-CoV-2 co-infection cases in the upcoming flu season.