How disturbed sleep may be a risk factor for adverse pregnancy outcomes.
How disturbed sleep may be a risk factor for adverse pregnancy outcomes.
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DOI：
10.1097/ogx.0b013e318195160e
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发表时间：
2009-04
影响因子：
6.2
通讯作者：
Hall M
中科院分区：
文献类型：
--
作者：
Okun ML;Roberts JM;Marsland AL;Hall M
在西方社会，尽管医疗技术不断进步，但与孕产妇和婴儿发病率显著相关的不良妊娠结局仍在上升。目前的风险因素不足以确定最有可能发生不良后果的妇女。有必要尝试识别导致风险增加的新因素。睡眠障碍在怀孕期间很常见，但往往被认为是无关紧要的。新的证据表明，睡眠障碍与不良的健康结果有关，包括心血管疾病。睡眠障碍还与炎症反应增加有关。炎症增加被认为是慢性疾病和不良妊娠结局发展的关键生物学途径。在本文中，我们提出了一个模型和一个可检验的假设，即妊娠前20周的睡眠紊乱如何通过增加炎症导致不良妊娠结局，如先兆子痫、宫内生长受限和早产。在完成这篇文章后，读者应该能够概述将睡眠障碍与某些全身性疾病风险增加联系起来的数据，回忆支持睡眠障碍可能与这些妊娠结局相关的假设的妊娠并发症的特征，并总结孕妇常见的睡眠障碍的可能性和类型。
Adverse pregnancy outcomes associated with significant maternal and infant morbidity are on the rise in Western society despite advances of medical technology. Current risk factors are insufficient to identify women at greatest risk of developing an adverse outcome. An attempt to identify novel contributors to increased risk is warranted. Sleep disturbances are frequent during pregnancy, yet are often dismissed as irrelevant. Emerging evidence indicates that sleep disturbances are associated with poor health outcomes, including cardiovascular disease. Disturbed sleep is also linked with an increased inflammatory response. Increased inflammation is proposed as a key biological pathway through which chronic disease and adverse pregnancy outcomes develop. In this paper, we propose a model and a testable hypothesis of how disturbed sleep in the first 20 weeks of pregnancy could contribute to adverse pregnancy outcomes such as preeclampsia, intrauterine growth restriction, and preterm birth via increased inflammation. Obstetricians & Gynecologists, Family Physicians After completion of this article, the reader should be able to outline data linking sleep disturbances with an increased risk of some systemic disorders, recall characteristics of pregnancy complications which support the hypothesis that sleep disturbances may be related to these pregnancy outcomes, and summarize the likelihood and types of sleep disturbances that are common in pregnant women.