HIV Antiretroviral Medication Neuropenetrance and Neurocognitive Outcomes in HIV+ Adults: A Review of the Literature Examining the Central Nervous System Penetration Effectiveness Score.
HIV Antiretroviral Medication Neuropenetrance and Neurocognitive Outcomes in HIV+ Adults: A Review of the Literature Examining the Central Nervous System Penetration Effectiveness Score.
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HIV抗逆转录病毒药物的神经培训和HIV+成人的神经认知结果：研究中枢神经系统渗透有效性评分的文献综述。
DOI：
10.3390/v14061151
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发表时间：
2022-05-26
期刊：
影响因子：
--
通讯作者：
中科院分区：
文献类型：
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作者：
该文献综述总结了现有的研究，研究CNS渗透有效性（CPE）评分和神经认知结局（即，神经心理学评估和神经认知筛查）。尽管联合抗逆转录病毒治疗（CART）在降低HIV死亡率和发病率以及控制病毒复制方面有效，但HIV通常在中枢神经系统（CNS）中持续存在，神经认知障碍的发生率仍然高于后CART时代的预测。CPE评分是根据抗逆转录病毒治疗穿透中枢神经系统的能力和抑制病毒的效力对抗逆转录病毒治疗方案进行排名的，十多年来一直在研究其与神经认知功能的关系。基于23项研究的结果，我们得出结论，CPE与神经认知结果的相关性并不像最初假设的那样强，尽管CPE较高的抗逆转录病毒治疗方案可能与总体神经认知功能的适度改善结果相关，并且在较小程度上与注意力/工作记忆和学习/记忆相关。然而，结论受到研究设计和方法异质性的限制，并且缺乏更新的CPE指标。建议在这一领域的未来研究采用全面的，标准化的神经心理测试电池和检查域级的性能，并使用更新的2010年CPE指标，虽然更新的CPE排名是迫切需要的。
This literature review summarizes the existing research examining the CNS penetration effectiveness (CPE) score and neurocognitive outcomes (i.e., neuropsychological assessment and neurocognitive screening) in HIV+ individuals. Despite the effectiveness of Combined Antiretroviral Therapy (CART) in reducing mortality and morbidity in HIV and controlling viral replication, HIV often persists in the Central Nervous System (CNS), and rates of neurocognitive impairment remain higher than predicted in the post-CART era. The CPE score was developed to rank antiretroviral regimens on their ability to penetrate the CNS and potency in inhibiting the virus, and it has been examined in relation to neurocognitive functioning for over a decade. Based on the results of 23 studies, we conclude that CPE is not as strongly associated with neurocognitive outcomes as initially hypothesized, although higher CPE ARV regimens may be associated with modest, improved outcomes in global neurocognitive functioning, and to a lesser extent attention/working memory and learning/memory. Conclusions, however, are limited by the heterogeneity in study design and methods, and the lack of a more recent CPE metric update. It is recommended that future research in this area employ comprehensive, standardized neuropsychological test batteries and examine domain-level performance, and use the newer 2010 CPE metric, although an updated CPE ranking is urgently needed.
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DOI：
10.1007/s11481-015-9610-4
发表时间：
2015-09
期刊：
Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology
影响因子：
--
作者：
Baker LM;Paul RH;Heaps-Woodruff JM;Chang JY;Ortega M;Margolin Z;Usher C;Basco B;Cooley S;Ances BM
通讯作者：
Ances BM
影响因子：
11.8
作者：
Ellis, Ronald J.;Letendre, Scott;McCutchan, J. Allen
通讯作者：
McCutchan, J. Allen
影响因子：
11.8
作者：
Antinori, Andrea;Arendt, Gabriele;Munoz-Moreno, Jose A.
通讯作者：
Munoz-Moreno, Jose A.
影响因子：
9.9
作者：
Ellis, RJ;Gamst, AC;McCutchan, JA
通讯作者：
McCutchan, JA
影响因子：
1.2
作者：
Fabbiani, Massimiliano;Grima, Pierfrancesco;Di Giambenedetto, Simona
通讯作者：
Di Giambenedetto, Simona