Differential Role of Transforming Growth Factor-beta in an Osteoarthritic or a Healthy Joint.
Differential Role of Transforming Growth Factor-beta in an Osteoarthritic or a Healthy Joint.
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DOI：
10.11005/jbm.2018.25.2.65
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发表时间：
2018-05
影响因子：
--
通讯作者：
van der Kraan PM
中科院分区：
文献类型：
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作者：
van der Kraan PM
转化生长因子-β(转化生长因子-β)是一种细胞因子，在正常关节和最常见的关节疾病骨关节炎(OA)的关节中都发挥着重要作用。然而，这种多效性细胞因子在正常健康关节中的作用与其在骨关节炎关节中的作用截然不同。在正常滑膜关节中，活性的转化生长因子-β只有在关节负荷后才存在，并且只存在很短的一段时间。相反，在骨关节炎关节中检测到永久性的和高水平的活性转化生长因子-β。由于关节细胞对活性转化生长因子-β水平和暴露时间的不同，转化生长因子-β在正常关节和骨关节炎关节中的功能存在显著差异。在这篇综述中讨论了转化生长因子-β水平的这种差异对关节内稳态和骨关节炎关节的病理变化的影响。
Transforming growth factor-β (TGF-β) is a cytokine that plays an important role in both normal joints and joints affected by osteoarthritis (OA), the most common joint disease. However, the role of this pleiotropic cytokine in a normal healthy joint is very different from its role in an OA joint. In a normal synovial joint, active TGF-β is only present after joint loading and only for a short period. In contrast, permanent and high levels of active TGF-β are detected in OA joints. Due to this difference in levels and exposure period of joint cells to active TGF-β, the function of TGF-β is strikingly different in normal and OA joints. The consequences of this difference in TGF-β levels on joint homeostasis and pathological changes in OA joints are discussed in this review.