Mitochondrial Dysfunction Is a Common Denominator Linking Skeletal Muscle Wasting Due to Disease, Aging, and Prolonged Inactivity.
Mitochondrial Dysfunction Is a Common Denominator Linking Skeletal Muscle Wasting Due to Disease, Aging, and Prolonged Inactivity.
复制标题
DOI：
10.3390/antiox10040588
复制
发表时间：
2021-04-11
期刊：
影响因子：
--
通讯作者：
Powers SK
中科院分区：
文献类型：
--
作者：
Hyatt HW;Powers SK
骨骼肌是身体中最丰富的组织，并且是许多重要功能所必需的，包括呼吸和运动。值得注意的是，骨骼肌质量的恶化也与患有慢性疾病（例如，癌症）。许多条件可以促进骨骼肌萎缩，包括几种慢性疾病，癌症化疗，衰老和长期不活动。虽然造成这种肌肉质量损失的机制是多因素的，但线粒体功能障碍预计是各种条件下肌肉萎缩的主要原因。这篇系统性综述将强调已被证明将线粒体功能障碍与骨骼肌萎缩联系起来的生化途径。重要的是，我们将讨论将线粒体功能障碍与特定疾病中的肌肉萎缩联系起来的实验证据（即，癌症和脓毒症）、衰老、癌症化疗，和延长的肌肉不活动（例如，肢体固定）。最后，希望刺激未来的研究，我们结束了在肌肉萎缩领域的研究的重要未来方向的讨论。
Skeletal muscle is the most abundant tissue in the body and is required for numerous vital functions, including breathing and locomotion. Notably, deterioration of skeletal muscle mass is also highly correlated to mortality in patients suffering from chronic diseases (e.g., cancer). Numerous conditions can promote skeletal muscle wasting, including several chronic diseases, cancer chemotherapy, aging, and prolonged inactivity. Although the mechanisms responsible for this loss of muscle mass is multifactorial, mitochondrial dysfunction is predicted to be a major contributor to muscle wasting in various conditions. This systematic review will highlight the biochemical pathways that have been shown to link mitochondrial dysfunction to skeletal muscle wasting. Importantly, we will discuss the experimental evidence that connects mitochondrial dysfunction to muscle wasting in specific diseases (i.e., cancer and sepsis), aging, cancer chemotherapy, and prolonged muscle inactivity (e.g., limb immobilization). Finally, in hopes of stimulating future research, we conclude with a discussion of important future directions for research in the field of muscle wasting.
登录
查看更多内容
DOI：
10.1002/jcsm.12232
发表时间：
2017-12
期刊：
Journal of cachexia, sarcopenia and muscle
影响因子：
--
作者：
Brown JL;Rosa-Caldwell ME;Lee DE;Blackwell TA;Brown LA;Perry RA;Haynie WS;Hardee JP;Carson JA;Wiggs MP;Washington TA;Greene NP
通讯作者：
Greene NP
影响因子：
4.7
作者：
Batsis, J. A.;Mackenzie, T. A.;Bartels, S. J.
通讯作者：
Bartels, S. J.
影响因子：
15.9
作者：
Anderson, Ethan J.;Lustig, Mary E.;Neufer, P. Darrell
通讯作者：
Neufer, P. Darrell
DOI：
10.1152/ajpregu.00432.2003
发表时间：
2004-03-01
影响因子：
2.8
作者：
Brealey, D;Karyampudi, S;Singer, M
通讯作者：
Singer, M
影响因子：
4.8
作者：
Anderson, Ethan J.;Yamazaki, Hanae;Neufer, P. Darrell
通讯作者：
Neufer, P. Darrell