Acute and residual interactive effects of repeated administrations of oral methamphetamine and alcohol in humans
Acute and residual interactive effects of repeated administrations of oral methamphetamine and alcohol in humans
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DOI：
10.1007/s00213-011-2390-5
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发表时间：
2012-01-01
影响因子：
3.4
通讯作者：
Hart, Carl L.
中科院分区：
文献类型：
--
作者：
Kirkpatrick, Matthew G.;Gunderson, Erik W.;Hart, Carl L.
虽然甲基苯丙胺和酒精通常以类似狂欢的模式一起使用，但缺乏调查这种药物组合重复作用的经验数据。目前的研究探讨了急性和残留的情绪，性能和生理影响甲基苯丙胺单独，酒精单独和组合。9名成年男性志愿者完成了这项为期20天的参与者内住宅实验室研究。在四个为期5天的阶段中，参与者被给予口服甲基苯丙胺（0，10毫克）与酒精（0，0.375，0.75克/公斤）三次（第2天：上午，第2天：下午，第3天：下午）。在给药前和给药后重复评估呼气酒精浓度、心血管、主观和认知/精神表现效应。还评估了主观和客观睡眠测量;在每个区块的第3-5天评估残余效应。在第一次给药后，与单独使用任何一种药物相比，甲基苯丙胺-酒精组合产生了更大的心率升高和“良好药物效果”的评级。甲基苯丙胺减弱酒精相关的性能下降和醉酒的感觉，而酒精衰减甲基苯丙胺相关的睡眠中断。到第三次给药时，这些影响中的许多都显着减弱，表明参与者产生了耐受性。几乎没有观察到残留效应。这些数据表明，甲基苯丙胺与酒精结合产生的效果与单独使用任何一种药物的效果不同。药物组合的主要积极作用（即，更大的欣快感，更少的表现和睡眠中断）可能解释了为什么这些药物经常被联合使用。
Although methamphetamine and alcohol are commonly used together in a binge-like pattern, there is a dearth of empirical data investigating the repeated effects of this drug combination. The current study examined acute and residual mood, performance, and physiological effects of methamphetamine alone, alcohol alone, and the combination. Nine adult male volunteers completed this 20-day within-participant, residential laboratory study. During four 5-day blocks of sessions, participants were administered oral methamphetamine (0, 10 mg) combined with alcohol (0, 0.375, 0.75 g/kg) three times (day 2: AM, day 2: PM, and day 3: PM). Breath alcohol concentrations, cardiovascular, subjective, and cognitive/psychomotor performance effects were assessed before drug administration and repeatedly thereafter. Subjective and objective sleep measures were also assessed; residual effects were assessed on days 3-5 of each block. Following the first drug administration, the methamphetamine-alcohol combination produced greater elevations of heart rate and ratings of "good drug effect" compared to either drug alone. Methamphetamine attenuated alcohol-related performance decrements and feelings of intoxication, whereas alcohol attenuated methamphetamine-related sleep disruptions. By the third administration, many of these effects were significantly diminished, suggesting that participants developed tolerance. Few residual effects were observed. These data show that methamphetamine combined with alcohol produced a profile of effects that was different from the effects of either drug alone. The largely positive effects of the drug combination (i.e., greater euphoria, and fewer performance and sleep disruptions) might explain why these drugs are often used in combination.