Contribution of BlaA and BlaB β-Lactamases to Antibiotic Susceptibility of Yersinia enterocolitica Biovar 1B
Contribution of BlaA and BlaB β-Lactamases to Antibiotic Susceptibility of Yersinia enterocolitica Biovar 1B
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DOI：
10.1128/aac.01754-09
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发表时间：
2010-09-01
影响因子：
4.9
通讯作者：
Young, Glenn M.
中科院分区：
文献类型：
--
作者：
Bent, Zachary W.;Young, Glenn M.
高致病性小肠结肠炎耶尔森菌生物变种1B产生两种不同的β -内酰胺酶BlaA和BlaB。构建了具有代表性的生物多样性1B分离物的突变体并进行了评估，以确定BlaA和BlaB对广谱β -内酰胺类抗生素的敏感性限制程度。结果表明，a类酶BlaA在限制青霉素类和头孢菌素类药物的敏感性中起重要作用。C类酶BlaB的作用不那么深刻，主要局限于头孢菌素敏感性。
Highly pathogenic Yersinia enterocolitica biovar 1B produces two distinct beta-lactamases, BlaA and BlaB. Mutants of a representative biovar 1B isolate were constructed and evaluated to determine the extent of limitation of susceptibility to broad-spectrum beta-lactam antibiotics by BlaA and BlaB. The results demonstrated that BlaA, a class A enzyme, plays a significant role in limiting susceptibility to penicillins and cephalosporins. The contribution of BlaB, a class C enzyme, was less profound and was limited primarily to cephalosporin susceptibility.