INHERITANCE AND PATHOGENESIS OF HYDROCEPHALUS-3 IN MOUSE
INHERITANCE AND PATHOGENESIS OF HYDROCEPHALUS-3 IN MOUSE
复制标题
DOI：
10.1002/path.1700810119
复制
发表时间：
1961-01-01
期刊：
影响因子：
--
通讯作者：
BERRY, RJ
中科院分区：
文献类型：
--
作者：
BERRY, RJ
hy-3 是一种表达性和外显率相当低的隐性基因，可在出生时产生内部交通性脑积水。这是由脑膜的退行性变化引起的，脑膜的退行性变化似乎与颅骨上层骨骼的骨化有关。在 +/hy-3 动物中也可以发现类似的退行性变化，但在杂合子中尚未观察到任何临床症状。
hy-3 is a recessive gene of fairly low expressivity and penetrance which produces an internal, communicating hydrocephalus developing around the time of birth. This is produced by degenerative changes in the meninges which seem to be associated with ossification of the overlying bones of the skull. Similar degenerative changes can be found in +/hy-3 animals, but no clinical signs have ever been seen in a heterozygote.