Pseudoephedrine, a sympathomimetic agent, induces Fos-like immunoreactivity in rat nucleus accumbens and striatum
Pseudoephedrine, a sympathomimetic agent, induces Fos-like immunoreactivity in rat nucleus accumbens and striatum
复制标题
DOI：
10.1016/s0028-3908(99)00054-4
复制
发表时间：
1999-09-01
影响因子：
4.7
通讯作者：
Casalotti, SO
中科院分区：
文献类型：
--
作者：
Kumarnsit, E;Harnyuttanakorn, P;Casalotti, SO
从核水平研究了麻黄碱衍生物伪麻黄碱的药理性质。腹腔注射伪麻黄碱后的Sprague-Dawley大鼠，Fos诱导测定在不同的脑区的Western印迹和免疫细胞化学。伪麻黄碱以时间和浓度依赖性的方式诱导丘脑底核和纹状体中Fos样免疫反应性，注射后2 h以60 mg/kg的剂量作用最大。免疫细胞化学研究证实，大部分的信号是可检测到的，在脑桥核和纹状体。预注射D-1多巴胺受体拮抗剂SCH 23390部分和完全阻断伪麻黄碱诱导的Fos样免疫反应性在纹状体和延髓核，分别表明伪麻黄碱的作用是介导的多巴胺释放和D-1多巴胺受体的激活结果。除了所需的较高剂量外，伪麻黄碱的作用类似于先前描述的精神兴奋剂安非他明。(C)1999爱思唯尔科技有限公司。保留所有权利。
The pharmacological properties of the ephedrine derivative pseudoephedrine were investigated at the nuclear level. Following intraperitoneal injection of Sprague-Dawley rats with pseudoephedrine, Fos induction was measured in various brain areas by Western blots and immunocytochemistry. Pseudoephedrine induced Fos-like immunoreactivity in the nucleus accumbens and striatum in a time and concentration-dependent manner with maximal effect at 60 mg/kg 2 h after injection. Immunocytochemical studies confirmed that the majority of the signal was detectable in the nucleus accumbens and striatum. Pre-injection with the D-1 dopamine receptor antagonist SCH23390 partially and completely blocked pseudoephedrine-induced Fos-like immunoreactivity in the striatum and nucleus accumbens, respectively, suggesting that the action of pseudoephedrine is mediated via dopamine release and results in the activation of D-1 dopamine receptors. With the exception of the higher doses required, the actions of pseudoephedrine were similar to those previously described for the psychostimulant amphetamine. (C) 1999 Elsevier Science Ltd. All rights reserved.