Studies on the effects of cyclosporin A upon renal allograft rejection in the dog.
Studies on the effects of cyclosporin A upon renal allograft rejection in the dog.
复制标题
环孢菌素 A 对狗肾同种异体移植排斥反应影响的研究。
DOI：
10.5555/uri:pii:0039606080900227
复制
发表时间：
1980
期刊：
影响因子：
3.8
通讯作者：
Peter J. Morris
中科院分区：
文献类型：
--
作者：
W. Homan;French Me;Peter R. Millard;T. Denton;John W. Fabre;Peter J. Morris
新型免疫抑制剂环孢素A的剂量和时间效应研究已经在狗的同种异体肾移植模型中进行。连续服用20 mg/kg/d的6只犬中只有1只发生了移植肾排斥反应，而每天服用10 mg/kg的11只犬中有10只发生了排斥反应。每天给药10或20 mg/kg，连续给药2或3周可延缓排斥反应，但停药后所有动物均发生排斥反应。这表明，该药物不会克隆删除参与对移植物的免疫反应的淋巴细胞，而只是抑制它们。治疗剂量的环孢素A可显著改善排斥反应的组织学图像，即使在较高剂量的试验中也没有发现一致的组织学或生化证据表明存在肝毒性或肾毒性。在29只接受5毫克/公斤/天或更高剂量的狗中，发现1例致命性和4例非致命性感染并发症。
Dose and time response studies of the new immunosuppressive agent, cyclosporin A, have been performed in a dog renal allograft model. Rejection of a renal allograft only occurred in one of six dogs receiving 20 mg/kg/day continuously, but in 10 of 11 dogs receiving 10 mg/kg/day. Doses of 10 or 20 mg/kg/day given for 2 or 3 weeks delayed rejection, but rejection occurred in all animals when the drug was stopped. This suggests that the drug does not produce clonal deletion of the lymphocytes engaged in the immune reaction against the graft, but merely their suppression. The histological picture of rejection was markedly improved by therapeutic doses of cyclosporin A. No consistent histological or biochemical evidence for heptatoxicity or nephrotoxicity was found even in the higher doses tested. One fatal and four non-fatal infectious complications were seen in 29 dogs receiving doses of 5 mg/kg/day or higher.