X-rays can trigger the FLASH effect: Ultra-high dose-rate synchrotron light source prevents normal brain injury after whole brain irradiation in mice
X-rays can trigger the FLASH effect: Ultra-high dose-rate synchrotron light source prevents normal brain injury after whole brain irradiation in mice
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DOI：
10.1016/j.radonc.2018.08.016
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发表时间：
2018-12-01
影响因子：
5.7
通讯作者：
Vozenin, Marie-Catherine
中科院分区：
文献类型：
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作者：
Montay-Gruel, Pierre;Bouchet, Audrey;Vozenin, Marie-Catherine
这项研究首次证明了 X 射线可以触发闪光效应。我们的结果表明，同步加速器产生的 X 射线以超高剂量率进行 10 Gy 全脑照射不会引起记忆缺陷；它减少海马细胞分裂损伤并诱导较少的反应性星形胶质细胞增生。 (C) 2018 年由 Elsevier B.V. 出版
This study is the first proof of concept that the FLASH effect can be triggered by X-rays. Our results show that a 10 Gy whole-brain irradiation delivered at ultra-high dose-rate with synchrotron generated X-rays does not induce memory deficit; it reduces hippocampal cell-division impairment and induces less reactive astrogliosis. (C) 2018 Published by Elsevier B.V.