Solid-phase synthesis of DNA-encoded libraries via an "aldehyde explosion" strategy
Solid-phase synthesis of DNA-encoded libraries via an "aldehyde explosion" strategy
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DOI：
10.1039/d0cc01474e
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发表时间：
2020-04-30
影响因子：
4.9
通讯作者：
Kodadek, Thomas
中科院分区：
文献类型：
--
作者：
Paciaroni, Nicholas G.;Ndungu, John M.;Kodadek, Thomas
我们报告的化学适合于固相合成的DNA编码的库具有异常高的水平的结构多样性。该策略涉及在DNA相容的条件下将固定的醛“爆炸”成过多的不同官能团。
We report chemistry suitable for the solid-phase synthesis of DNA-encoded libraries with an unusually high level of structural diversity. The strategy involves "exploding" an immobilized aldehyde into a plethora of different functional groups under DNA-compatible conditions.