Inflammation and plaque vulnerability.
Inflammation and plaque vulnerability.
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DOI：
10.1111/joim.12406
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发表时间：
2015-11
影响因子：
11.1
通讯作者：
Tabas I
中科院分区：
文献类型：
--
作者：
Hansson GK;Libby P;Tabas I
动脉粥样硬化是一种适应不良、无法缓解的慢性炎症性疾病，发生在血流紊乱部位。这种疾病通常会保持沉默，直到动脉表面完整性破坏引发血栓形成。通过闭塞管腔，从中脱离的血栓或栓子会引发可能危及生命的缺血症状。两种类型的表面损伤可导致动脉粥样硬化血栓形成：斑块破裂和内皮侵蚀。斑块破裂被认为是由于机械稳定性丧失引起的，通常是由于斑块周围胶原帽的拉伸强度降低所致。因此，胶原蛋白含量减少的斑块被认为比胶原蛋白帽较厚的斑块更容易受到伤害。另一方面，内皮侵蚀可能发生在代谢紊乱或免疫损伤引起的内皮损伤之后。本综述讨论了斑块脆弱性和动脉粥样硬化血栓形成的分子机制。
Atherosclerosis is a maladaptive, nonresolving chronic inflammatory disease that occurs at sites of blood flow disturbance. The disease usually remains silent until a breakdown of integrity at the arterial surface triggers the formation of a thrombus. By occluding the lumen, the thrombus or emboli detaching from it elicits ischaemic symptoms that may be life-threatening. Two types of surface damage can cause atherothrombosis: plaque rupture and endothelial erosion. Plaque rupture is thought to be caused by loss of mechanical stability, often due to reduced tensile strength of the collagen cap surrounding the plaque. Therefore, plaques with reduced collagen content are thought to be more vulnerable than those with a thick collagen cap. Endothelial erosion, on the other hand, may occur after injurious insults to the endothelium instigated by metabolic disturbance or immune insults. This review discusses the molecular mechanisms involved in plaque vulnerability and the development of atherothrombosis.
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影响因子：
15.9
作者：
GALIS, ZS;SUKHOVA, GK;LIBBY, P
通讯作者：
LIBBY, P
影响因子：
17.1
作者：
Gistera, Anton;Robertson, Anna-Karin L.;Hansson, Goeran K.
通讯作者：
Hansson, Goeran K.
DOI：
10.1161/01.atv.11.5.1223
发表时间：
1991-09-01
期刊：
ARTERIOSCLEROSIS AND THROMBOSIS
影响因子：
--
作者：
AMENTO, EP;EHSANI, N;LIBBY, P
通讯作者：
LIBBY, P
影响因子：
32.4
作者：
Choi, Jae-Hoon;Cheong, Cheolho;Steinman, Ralph M.
通讯作者：
Steinman, Ralph M.
影响因子：
158.5
作者：
DAVIES, MJ;THOMAS, A
通讯作者：
THOMAS, A