NKG2D signaling is coupled to the interleukin 15 receptor signaling pathway
NKG2D signaling is coupled to the interleukin 15 receptor signaling pathway
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DOI：
10.1038/ni1524
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发表时间：
2007-12-01
影响因子：
30.5
通讯作者：
Medzhitov, Ruslan
中科院分区：
文献类型：
--
作者：
Horng, Tiffany;Bezbradica, Jelena S.;Medzhitov, Ruslan
自然杀伤细胞的效应器功能由活化受体调节，所述活化受体识别在靶细胞上表达的应激诱导配体并通过与信号传导衔接子缔合而发出信号。在这里，我们开发了一种小鼠模型，其中信号适配器DAP 10和泛素的融合有效地下调了自然杀伤细胞表面活化受体NKG2D的表达。利用该系统，我们鉴定了由NKG2D和DAP 10触发的信号通路与由白细胞介素15受体启动的信号通路的偶联。我们认为，这种激活受体与其他受体系统的耦合可以更普遍地在不同的生理环境中调节细胞类型特异性信号传导事件。
The effector functions of natural killer cells are regulated by activating receptors, which recognize stress-inducible ligands expressed on target cells and signal through association with signaling adaptors. Here we developed a mouse model in which a fusion of the signaling adaptor DAP10 and ubiquitin efficiently downregulated expression of the activating receptor NKG2D on the surfaces of natural killer cells. With this system, we identified coupling of the signaling pathways triggered by NKG2D and DAP10 to those initiated by the interleukin 15 receptor. We suggest that this coupling of activating receptors to other receptor systems could function more generally to regulate cell type-specific signaling events in distinct physiological contexts.