Lipopolysaccharide pretreatment inhibits LPS-induced human umbilical cord mesenchymal stem cell apoptosis via upregulating the expression of cellular FLICE-inhibitory protein.
Lipopolysaccharide pretreatment inhibits LPS-induced human umbilical cord mesenchymal stem cell apoptosis via upregulating the expression of cellular FLICE-inhibitory protein.
复制标题
脂多糖预处理通过上调细胞FLICE抑制蛋白的表达抑制LPS诱导的人脐带间充质干细胞凋亡
DOI：
10.3892/mmr.2015.3723
复制
发表时间：
2015-08
影响因子：
3.4
通讯作者：
Ma L
中科院分区：
文献类型：
--
作者：
Hou YS;Liu LY;Chai JK;Yu YH;Duan HJ;Hu Q;Yin HN;Wang YH;Zhuang SB;Fan J;Chu WL;Ma L
Mesenchymal stem cell (MSC)-based regenerative therapy is currently regarded as a novel approach with which to repair damaged tissues. However, the efficiency of MSC transplantation is limited due to the low survival rate of engrafted MSCs. Lipopolysaccharide (LPS) production is increased in numerous diseases and serves an essential function in the regulation of apoptosis in a variety of cell types. Previous studies have indicated that low-dose LPS pretreatment contributes to cytoprotection. In the current study, LPS was demonstrated to induce apoptosis in human umbilical cord mesenchymal stem cells (hUCMSCs) via the activation of caspase, in a dose-dependent manner. Low-dose LPS pretreatment may protect hUCMSCs against apoptosis induced by high-dose LPS, by upregulating the expression of cellular FADD-like IL-1β-converting enzyme-inhibitory protein (c-FLIP). The results of the present study indicate that pretreatment with an appropriate concentration of LPS may alleviate high-dose LPS-induced apoptosis.
登录
查看更多内容
影响因子：
4.4
作者：
Chiou, SH;Liu, JH;Wu, CW
通讯作者：
Wu, CW
影响因子：
11.4
作者：
Chang, DW;Xing, Z;Yang, XL
通讯作者：
Yang, XL
影响因子：
4.4
作者：
Jung, DY;Lee, H;Suk, K
通讯作者：
Suk, K
影响因子：
2.7
作者：
Burlacu, Alexandrina
通讯作者：
Burlacu, Alexandrina
影响因子：
--
作者：
Bai, SC;Liu, HT;Pope, RM
通讯作者：
Pope, RM