THE CELLULOSOME - A TREASURE-TROVE FOR BIOTECHNOLOGY
THE CELLULOSOME - A TREASURE-TROVE FOR BIOTECHNOLOGY
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DOI：
10.1016/0167-7799(94)90039-6
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发表时间：
1994-09-01
影响因子：
17.3
通讯作者：
LAMED, R
中科院分区：
文献类型：
--
作者：
BAYER, EA;MORAG, E;LAMED, R
许多纤维素分解细菌的纤维素酶被组织成离散的多酶复合物，称为纤维素体。纤维素体的多个亚基由许多功能域组成，这些功能域相互作用并与纤维素底物相互作用。其中一个亚基包括一种独特的新型非催化支架多肽，它选择性地将各种纤维素酶和木聚糖酶亚基整合到内聚复合物中。智能应用纤维素杂交体和纤维体结构域的嵌合结构应该能够更好地利用纤维素生物质，并可能在研究，医学和工业中提供广泛的新应用。
The cellulases of many cellulolytic bacteria are organized into discrete multienzyme complexes, called cellulosomes. The multiple subunits of cellulosomes are composed of numerous functional domains, which interact with each other and with the cellulosic substrate. One of these subunits comprises a distinctive new class of noncatalytic scaffolding polypeptide, which selectively integrates the various cellulase and xylanase subunits into the cohesive complex. Intelligent application of cellulosome hybrids and chimeric constructs of cellulosomal domains should enable better use of cellulosic biomass and may offer a wide range of novel applications in research, medicine and industry.