Psychobiological effects of prenatal glucocorticoid exposure in 10-year-old-children.
Psychobiological effects of prenatal glucocorticoid exposure in 10-year-old-children.
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DOI：
10.3389/fpsyt.2012.00104
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发表时间：
2012
影响因子：
4.7
通讯作者：
Ehlert U
中科院分区：
文献类型：
--
作者：
Erni K;Shaqiri-Emini L;La Marca R;Zimmermann R;Ehlert U
背景：产前应激似乎对后代的生理和心理过程具有长期影响。然而，迄今为止，还没有研究调查产前糖皮质激素暴露对儿童心理，内分泌和自主神经对标准化心理社会压力测试的反应的影响。方法：对115名10岁健康儿童进行了检查。糖皮质激素+安胎药组的特征是对早产母亲进行安胎治疗（n = 43）。此外，孕妇接受糖皮质激素治疗，以便在早产的情况下加速胎肺成熟。第一个对照组（安胎药）由母亲也经历早产但未接受糖皮质激素治疗的儿童组成（n = 35）。在第二个对照组（对照组）中，评估了母亲无并发症妊娠的儿童（n = 37）。心理参数（压力评估和情绪），使用自我报告问卷以及唾液皮质醇，唾液α-淀粉酶，和心率进行了测量，在标准化的心理社会压力测试（特里尔社会压力测试儿童）。结果如下：组间比较显示，产前暴露于糖皮质激素的儿童与两个对照组相比，压力评估子量表（控制期望）存在显著差异（F = 4.889，p = 0.009）。此外，唾液皮质醇组间的显着差异。关于总体压力评估和心率，三组之间观察到显著性趋势。结论：在10岁时，与对照组儿童相比，那些在产前暴露于母体糖皮质激素的儿童对标准化心理社会应激测试显示出改变的心理生物应激反应。
Background: Prenatal stress seems to have long-lasting effects on biological and psychological processes of the offspring. However, to date, there have been no studies investigating the effects of prenatal glucocorticoid exposure on psychological, endocrine, and autonomic responses to a standardized psychosocial stress test in children. Methods: A sample of 115 healthy, 10-year-old children was examined. The Glucocorticoids + Tocolytics group was characterized by tocolytic treatment of the mothers due to preterm labor (n = 43). In addition, the pregnant women received glucocorticoid treatment in order to accelerate fetal lung maturation in case of preterm birth. The first comparison group (Tocolytics) consisted of children whose mothers also experienced preterm labor, but did not receive glucocorticoid treatment (n = 35). In the second comparison group (CONTROL), children whose mothers had a complication-free pregnancy were assessed (n = 37). Psychological parameters (stress appraisal and mood) using self-report questionnaires as well as salivary cortisol, salivary alpha-amylase, and heart rate were measured during a standardized psychosocial stress test (Trier Social Stress Test for Children). Results: Group comparisons revealed that a subscale of stress appraisal, control expectancies, significantly differed in children who were prenatally exposed to glucocorticoids as compared to both comparison groups (F = 4.889, p = 0.009). Furthermore, significant differences between the groups were revealed for salivary cortisol. With respect to overall stress appraisal and heart rate, trends toward significance were observed between the three groups. Conclusion: At the age of ten, those children who have been exposed to prenatal maternal glucocorticoids show changed psychobiological stress reactivity to a standardized psychosocial stress test as compared to control children.