Preliminary evidence for a sex-specific relationship between amount of cannabis use and neurocognitive performance in young adult cannabis users.
Preliminary evidence for a sex-specific relationship between amount of cannabis use and neurocognitive performance in young adult cannabis users.
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年轻成人大麻使用者的大麻使用量与神经认知表现之间的性别特定关系的初步证据。
DOI：
10.1017/s135561771300088x
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发表时间：
2013-10
影响因子：
2.6
通讯作者：
Gonzalez, Raul
中科院分区：
文献类型：
--
作者：
Crane, Natania A.;Schuster, Randi Melissa;Gonzalez, Raul
越来越多的证据表明，大麻使用导致神经心理学缺陷，一个新兴的临床前研究领域表明可能存在性别差异。然而，很少有研究探讨大麻使用如何对男性和女性大麻使用者的神经认知产生不同的影响。因此，我们研究了大麻使用量（在几个时间范围内）与年轻成年常规大麻使用者的神经认知表现之间的潜在性别差异。与以前的研究一致，更多的大麻使用通常与较差的情景记忆和决策有关，但与其他抑制控制措施无关。然而，模式的结果表明性别特异性解离。特别是，更多的大麻使用与女性比男性更差的情景记忆表现更一致。相反，更多的大麻使用与男性决策能力较差有关，但与女性无关。这些结果为残留大麻相关的神经认知缺陷提供了进一步的证据，并表明了分别检查大麻对男性和女性神经认知的影响的重要性。
Accumulating evidence suggests neuropsychological deficits from cannabis use, with a burgeoning area of preclinical research indicating possible sex-differences. However, few studies have examined how cannabis use may differentially impact neurocognition in male and female cannabis users. As such, we examined potential sex-differences in associations between amount of cannabis use (across several time-frames) and neurocognitive performance among young adult regular cannabis users. Consistent with previous studies, more cannabis use was generally associated with poorer episodic memory and decision-making, but not other measures of inhibitory control. However, patterns of results suggested sex-specific dissociations. In particular, more cannabis use was more consistently associated with poorer episodic memory performance in females than males. Conversely, more cannabis use was associated with poorer decision-making performance for males, but not females. These results provide further evidence for residual cannabis-associated neurocognitive deficits and suggest the importance of examining the impact of cannabis on neurocognition separately for males and females.