A stressed barrier left behind: Stochastic podocyte ablation triggers secondary injury.
A stressed barrier left behind: Stochastic podocyte ablation triggers secondary injury.
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留下的压力屏障：随机足细胞消融引发继发性损伤。
DOI：
10.1152/ajprenal.00109.2021
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发表时间：
2021
期刊：
影响因子：
--
通讯作者：
Markus M. Rinschen
中科院分区：
文献类型：
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作者：
Sybille Koehler;Markus M. Rinschen
局灶节段性肾小球硬化（FSGS）是一种不充分表征的严重肾小球疾病。在疾病进展过程中，肾小球形成局灶性和节段性瘢痕，影响屏障功能并最终影响肾功能。FSGS起源于足细胞的损伤和丢失，足细胞与有孔内皮和肾小球基底膜（GBM）一起形成滤过屏障。足细胞损伤的潜在原因可能是遗传的、毒性的或免疫的。虽然一些研究已经调查了FSGS的机制，但这种疾病仍然是一个谜。尽管在该病的遗传学方面取得了重大进展，但我们仍然没有阐明这种异质性疾病的触发因素和驱动因素。可能，FSGS构成了许多不同的疾病，具有相同的组织学损伤模式。
Focal segmental glomerulosclerosis (FSGS) is an insufficiently characterized severe kidney disease that affects kidney glomeruli. During disease progression, glomeruli develop focal and segmental scars that affect the barrier function and, ultimately, kidney function. FSGS originates from damage and loss of podocytes that form the filtration barrier together with the fenestrated endothelium and glomerular basement membrane (GBM). The underlying cause of podocyte injury can be genetic, toxic, or immunological. Although several studies have investigated the mechanisms of FSGS, the disease remains enigmatic. Despite significant progress in the genetics of the disease, we still have not elucidated the triggers and drivers of this heterogeneous disease. Probably, FSGS constitutes many different diseases with the same histological injury pattern.
血管紧张素 II 受体阻滞剂可阻止部分足细胞切除模型中足细胞损伤的扩散
DOI：
--
发表时间：
2019
期刊：
影响因子：
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作者：
Okabe Masahiro ,Matsusaka Taiji
通讯作者：
Okabe Masahiro ,Matsusaka Taiji