Thymic function and peripheral T-cell homeostasis in rheumatoid arthritis
Thymic function and peripheral T-cell homeostasis in rheumatoid arthritis
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DOI：
10.1016/s1471-4906(00)01841-x
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发表时间：
2001-05-01
影响因子：
16.8
通讯作者：
Weyand, CM
中科院分区：
文献类型：
--
作者：
Goronzy, JJ;Weyand, CM
T 细胞多样性是通过产生新的胸腺移出物而产生的。胸腺功能随着年龄的增长而下降，T 细胞库通过初始外周 T 细胞的稳态增殖来维持。本文讨论胸腺输出和外周 T 细胞稳态对类风湿关节炎 (RA) 发展的影响。有人提出，RA 患者的胸腺输出过早受损。外周 T 细胞的代偿性扩张会导致其功能收缩和扭曲，可能有利于具有自身反应潜力的 T 细胞。 T 细胞群动态异常导致自身免疫风险增加，可能是慢性炎症性疾病的常见机制。
T-cell diversity is generated through the production of new thymic emigrants. Thymic function declines with age, and the T-cell pool is maintained through homeostatic proliferation of naive peripheral T cells. This article discusses the im pact of thymic output and peripheral T-cell homeostasis on the development of rheumatoid arthritis (RA). It is proposed that thymic output is prematurely compromised in RA patients. A compensatory expansion of peripheral T cells results in a contracted and distorted repertoire, possibly favoring T cells with autoreactive potential. Increased risk of autoimmunity, as a consequence of abnormal T-cell population dynamics, could be a common mechanism in chronic inflammatory diseases.