Regulation of systemic metabolism by tissue-resident immune cell circuits.
Regulation of systemic metabolism by tissue-resident immune cell circuits.
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DOI：
10.1016/j.immuni.2023.05.001
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发表时间：
2023-06
期刊：
影响因子：
32.4
通讯作者：
Joey H. Li;M. Hepworth;Timothy E. O’Sullivan
中科院分区：
文献类型：
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作者：
Joey H. Li;M. Hepworth;Timothy E. O’Sullivan
最近的研究表明，组织稳态和代谢功能依赖于不同的组织驻留免疫细胞，这些细胞与结构细胞形成功能性细胞回路。在这些细胞回路中，免疫细胞整合来自饮食内容和共生微生物的线索，以及存在于组织微环境中的内分泌和神经元信号，以调节结构细胞代谢。在炎症和饮食营养过剩期间，这些组织驻留的免疫回路可能变得失调，从而导致代谢疾病。在这里，我们回顾了描述肝脏、胃肠道和脂肪组织内部和之间控制全身代谢的关键细胞网络的证据，以及这些细胞回路在某些代谢疾病中如何变得失调。我们还确定了该领域的开放问题，这些问题有可能增强我们对代谢健康和疾病的理解。
Recent studies have demonstrated that tissue homeostasis and metabolic function are dependent on distinct tissue-resident immune cells that form functional cell circuits with structural cells. Within these cell circuits, immune cells integrate cues from dietary contents and commensal microbes in addition to endocrine and neuronal signals present in the tissue microenvironment to regulate structural cell metabolism. These tissue-resident immune circuits can become dysregulated during inflammation and dietary overnutrition, contributing to metabolic diseases. Here, we review the evidence describing key cellular networks within and between the liver, gastrointestinal tract, and adipose tissue that control systemic metabolism and how these cell circuits become dysregulated during certain metabolic diseases. We also identify open questions in the field that have the potential to enhance our understanding of metabolic health and disease.