MORPHOLOGICAL CLASSIFICATION OF RETINAL GANGLION-CELLS IN MICE
MORPHOLOGICAL CLASSIFICATION OF RETINAL GANGLION-CELLS IN MICE
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DOI：
10.1002/cne.903560305
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发表时间：
1995-06-05
影响因子：
2.5
通讯作者：
YAMAMURA, H
中科院分区：
文献类型：
--
作者：
DOI, M;UJI, Y;YAMAMURA, H
小鼠已被用于视神经和视网膜神经节细胞的广泛研究，但小鼠视网膜神经节细胞尚未进行形态学分类。在本研究中，正常放置的视网膜神经节细胞和色素和白化病小鼠的视网膜神经节细胞移位进行分类形态学使用辣根过氧化物酶。根据索马和树突野的大小，这些细胞被分为三种类型：I型细胞，大索马和大树突野; II型细胞，小至中等索马和小树突野;和III型细胞，小至中等索马和大树突野。有些神经节细胞既有对称细胞，也有不对称细胞。每种类型进一步细分根据内丛状层和树突的分支模式的树突的终止水平。除了III型移位的神经节细胞外，正常放置的神经节细胞和移位的神经节细胞的树突在内丛状层的外五分之二（sublamina a）或内丛状层的内五分之三（sublamina B）分支。III型移位的神经节细胞仅在亚板a中分叉。一些正常放置的I型神经节细胞的树突在两个亚板层中分叉。观察到移位的双丛状细胞，其树突在内丛状层和外丛状层中分叉。在两种小鼠品系中均发现了所有细胞类型。(C)1995年Wiley-Liss，Inc.
Mice have been used for extensive studies on optic nerves and retinal ganglion cells, but mouse retinal ganglion cells have not been classified morphologically. In the present study, normally placed retinal ganglion cells and displaced retinal ganglion cells in pigmented and albino mice were classified morphologically using horseradish peroxidase. These cells were classified into three types according to the sizes of the soma and the dendritic field; type I cells, large soma and large dendritic field; type II cells, small-to-medium soma and small dendritic field; and type III cells, small-to-medium soma and large dendritic field. Some ganglion cells had both symmetric and asymmetric cells. Each type was further subdivided according to the termination level of dendrites in the inner plexiform layer and the dendritic branching pattern. Except for type III displaced ganglion cells, dendrites of the normally placed ganglion cells and the displaced ganglion cells ramify in the outer two-fifths of the inner plexiform layer (sublamina a) or the inner three-fifths of the inner plexiform layer (sublamina b). Type III displaced ganglion cells ramify only in sublamina a. Dendrites of some normally placed type I ganglion cells ramify in both sublaminae. Displaced biplexiform cells were observed, the dendrites of which ramify in both the inner and the outer plexiform layers. All cell types were found in both mouse strains. (C) 1995 Wiley-Liss, Inc.