Quantitative, simultaneous PET/MRI for intratumoral imaging with an MRI-compatible PET scanner.
Quantitative, simultaneous PET/MRI for intratumoral imaging with an MRI-compatible PET scanner.
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DOI：
10.2967/jnumed.111.099861
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发表时间：
2012-07
期刊：
影响因子：
--
通讯作者：
Jacobs RE
中科院分区：
文献类型：
--
作者：
Ng TS;Bading JR;Park R;Sohi H;Procissi D;Colcher D;Conti PS;Cherry SR;Raubitschek AA;Jacobs RE
Noninvasive methods are needed to explore the heterogeneous tumor microenvironment and its modulation by therapy. Hybrid PET/MRI systems are being developed for small-animal and clinical use. The advantage of these integrated systems depends on their ability to provide MR images that are spatially coincident with simultaneously acquired PET images, allowing combined functional MRI and PET studies of intratissue heterogeneity. Although much effort has been devoted to developing this new technology, the issue of quantitative and spatial fidelity of PET images from hybrid PET/MRI systems to the tissues imaged has received little attention. Here, we evaluated the ability of a first-generation, small-animal MRI-compatible PET scanner to accurately depict heterogeneous patterns of radiotracer uptake in tumors. Quantitative imaging characteristics of the MRI-compatible PET (PET/MRI) scanner were evaluated with phantoms using calibration coefficients derived from a mouse-sized linearity phantom. PET performance was compared with a commercial small-animal PET system and autoradiography in tumor-bearing mice. Pixel and structure-based similarity metrics were used to evaluate image concordance among modalities. Feasibility of simultaneous PET/MRI functional imaging of tumors was explored by following 64Cu-labeled antibody uptake in relation to diffusion MRI using cooccurrence matrix analysis. The PET/MRI scanner showed stable and linear response. Activity concentration recovery values (measured and true activity concentration) calculated for 4-mm-diameter rods within linearity and uniform activity rod phantoms were near unity (0.97 ± 0.06 and 1.03 ± 0.03, respectively). Intratumoral uptake patterns for both 18F-FDG and a 64Cu-antibody acquired using the PET/MRI scanner and small-animal PET were highly correlated with autoradiography (r > 0.99) and with each other (r = 0.97 ± 0.01). On the basis of these data, we performed a preliminary study comparing diffusion MRI and radiolabeled antibody uptake patterns over time and visualized movement of antibodies from the vascular space into the tumor mass. The MRI-compatible PET scanner provided tumor images that were quantitatively accurate and spatially concordant with autoradiography and the small-animal PET examination. Cooccurrence matrix approaches enabled effective analysis of multimodal image sets. These observations confirm the ability of the current simultaneous PET/MRI system to provide accurate observations of intratumoral function and serve as a benchmark for future evaluations of hybrid instrumentation.
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影响因子：
9.3
作者：
Metz, Stephan;Ganter, Carl;Beer, Ambros J.
通讯作者：
Beer, Ambros J.
影响因子：
3.5
作者：
Yang, YF;Tai, YC;Cherry, SR
通讯作者：
Cherry, SR
影响因子：
4.9
作者：
Cherry SR
通讯作者：
Cherry SR
弥散加权磁共振成像和 2-[18F]-氟-2-脱氧-D-葡萄糖-正电子发射断层扫描成像生物标志物评估治疗相关炎症反应。
DOI：
10.1158/1078-0432.ccr-08-1812
发表时间：
2010-03-01
期刊：
Clinical cancer research : an official journal of the American Association for Cancer Research
影响因子：
--
作者：
Galbán CJ;Bhojani MS;Lee KC;Meyer CR;Van Dort ME;Kuszpit KK;Koeppe RA;Ranga R;Moffat BA;Johnson TD;Chenevert TL;Rehemtulla A;Ross BD
通讯作者：
Ross BD
影响因子：
3.5
作者：
Atuegwu NC;Gore JC;Yankeelov TE
通讯作者：
Yankeelov TE