Internal connectivity of the homing pigeon (Columba livia) hippocampal formation:: An anterograde and retrograde tracer study
Internal connectivity of the homing pigeon (Columba livia) hippocampal formation:: An anterograde and retrograde tracer study
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DOI：
10.1002/cne.10601
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发表时间：
2003-04-28
影响因子：
2.5
通讯作者：
Bingman, VP
中科院分区：
文献类型：
--
作者：
Kahn, MC;Hough, GE;Bingman, VP
鸟类海马形成（HF）是学习和记忆环境空间方面所必需的结构。因此，了解不同HF区域之间的联系对于确定鸟类大脑中空间学习过程的组织方式非常重要。哺乳动物海马中普遍存在的前馈、三突触内部连通性及其对认知的重要性已被很好地描述，但禽类HF的内部连通性直到最近才被研究。为了进一步研究禽HF内部的连通性，将少量霍乱毒素亚基B（主要是逆行示踪剂）（n = 15）或生物素化葡聚糖胺（主要是逆行示踪剂）（n = 10）注射到HF的局部区域。免疫组织化学标记组织的检查显示，外源性感觉加工区向背外侧HF和背内侧HF （DMd）的背侧部分投射。DMd依次投射到内侧（VM）和外侧（VL）腹侧细胞层。发现从VM到VL的投影，这些区域和DM一起提供对侧腹侧细胞层的输入。同侧，背内侧HF （DMv）的腹侧部分接收来自VL和VM的输入。从车管所看，投影从髋部侧面射出。突出显示的突起通过禽类HF形成了一个可辨的前馈处理网络，类似于哺乳动物HF的三突触回路。
The avian hippocampal formation (HF) is a structure necessary for learning and remembering aspects of environmental space. Therefore, understanding the connections between different HF regions is important for determining how spatial learning processes are organized within the avian brain. The prevailing feed-forward, trisynaptic internal connectivity of the mammalian hippocampus and its importance for cognition have been well described, but the internal connectivity of the avian HF has only recently been investigated. To examine further the connectivity within the avian HF, small amounts of cholera toxin subunit B, primarily a retrograde tracer (n = 15), or biotinylated dextran amine, primarily an anterograde tracer (n = 10), were injected into localized regions of the HF. Examination of the immunohistochemically labeled tissue showed projections from extrinsic sensory processing areas into dorsolateral HF and the dorsal portion of the dorsomedial HF (DMd). DMd in turn projected into the medial (VM) and lateral (VL) ventral cell layers. A projection from VM into VL was found, and together these areas and DM provided input into the contralateral ventral cell layers. Ipsilaterally, a ventral portion of dorsomedial HF (DMv) received input from VL and VM. From DMv, projections exited HIP laterally. The highlighted projections formed a discernible feed-forward processing network through the avian HF that resembled the trisynaptic circuit of the mammalian HF.