Nickel(0)-Catalyzed [2+2+1] Carbonylative Cycloaddition of Imines and Alkynes or Norbornene Leading to γ-Lactams
Nickel(0)-Catalyzed [2+2+1] Carbonylative Cycloaddition of Imines and Alkynes or Norbornene Leading to γ-Lactams
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DOI：
10.1021/ja509171a
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发表时间：
2014-11-12
影响因子：
15
通讯作者：
Ogoshi, Sensuke
中科院分区：
文献类型：
--
作者：
Hoshimoto, Yoichi;Ohata, Tomoya;Ogoshi, Sensuke
以甲酸苯酯为CO源，首次实现了镍（0）催化的亚胺与炔或异炔的[2 + 2 + 1]羰基环加成反应。用这种方法，可以以良好到高产率制备各种N-苯磺酰基、-甲苯磺酰基和-磷酰基取代的γ-内酰胺。
The first nickel(0)-catalyzed [2 + 2 + 1] carbonylative cycloaddition reaction of imines and alkynes or norbornene has been achieved by employing phenyl formate as a CO source. With this method, a variety of N-benzenesulfonyl, -tosyl, and -phosphoryl-substituted gamma-lactams can be prepared in good to high yields.