The role of superoxide anion radical in the reduction of ferritin iron by xanthine oxidase.
The role of superoxide anion radical in the reduction of ferritin iron by xanthine oxidase.
复制标题
超氧阴离子自由基在黄嘌呤氧化酶还原铁蛋白中的作用。
DOI：
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发表时间：
1974
影响因子：
15.9
通讯作者：
G. Cartwright
中科院分区：
文献类型：
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作者：
D. Williams;G. R. Lee;G. Cartwright
超氧化物歧化酶对黄嘌呤氧化酶介导的铁蛋白、氯化铁或ADP铁还原产生显著的抑制作用。当超氧化物歧化酶浓度仅为正常猪肝中的1%时，观察到最大抑制。这些观察结果表明，超氧阴离子自由基是体外黄嘌呤氧化酶还原铁的中间体，而不是在体内。
Superoxide dismutase exerted a pronounced inhibitory effect upon xanthine oxidase-mediated reduction of iron in ferritin, ferric chloride, or ferric ADP. Maximal inhibition was observed when the superoxide dismutase concentration was only about 1% of that found in normal porcine liver. These observations indicate that superoxide anion radical is an intermediate in the reduction of iron by xanthine oxidase in vitro but not in vivo.