EPISODIC HYPERTENSION DUE TO AUTONOMIC DYSREFLEXIA IN ACUTE AND CHRONIC SPINAL CORD-INJURED RATS
EPISODIC HYPERTENSION DUE TO AUTONOMIC DYSREFLEXIA IN ACUTE AND CHRONIC SPINAL CORD-INJURED RATS
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DOI：
10.1152/ajpheart.1995.268.5.h2077
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发表时间：
1995-05-01
影响因子：
4.8
通讯作者：
WEAVER, LC
中科院分区：
文献类型：
--
作者：
KRASSIOUKOV, AV;WEAVER, LC
脊髓损伤导致心血管系统的异常交感神经控制，包括过度反射，导致高血压和心动过缓，称为自主神经反射障碍。我们研究了在未麻醉的急性（7天）和慢性（30天）脊髓损伤大鼠中结肠或膀胱扩张引起的动脉压和心率的变化，以评估这些反应在脊髓损伤动物模型中的时间过程。在清醒对照大鼠中，结肠和膀胱扩张引起10 mmHg的短暂（2-10 s）按压反应，并伴有心动过速和逃逸反应。脊髓损伤大鼠的结肠扩张使动脉压分别在脊髓横断后24小时、7天和30天增加41 +/- 2、22 +/- 3和49 +/- 5 mmHg。这些反应持续30 s-5 min，并伴有心动过缓。脊髓横断后24小时和30天，膀胱扩张引起脊髓大鼠类似的反应。我们建议，最初的反应可能与脊髓反射下降抑制的损失，但在脊髓的可塑性变化是发生1个月后损伤的自主神经反射障碍的机制之一。
Spinal cord injury results in abnormal sympathetic control of the cardiovascular system, consisting of exaggerated reflexes with resulting hypertension and bradycardia that has been termed autonomic dysreflexia. We studied changes in arterial pressure and heart rate caused by colon or urinary bladder distension in unanesthetized acute (7 day) and chronic (30 day) spinal cord-injured rats to evaluate the time course of these responses in an animal model of spinal cord injury. In conscious control rats colon and bladder distension caused brief (2-10 s) presser responses of 10 mmHg associated with tachycardia and escape reactions. Colon distension in spinal cord-injured rats increased arterial pressure by 41 +/- 2, 22 +/- 3, and 49 +/- 5 mmHg at 24 h and 7 and 30 days after cord transection, respectively. These responses lasted 30 s-5 min and were accompanied by bradycardia. Distension of the urinary bladder caused similar responses in spinal rats after 24 h and 30 days of cord transection. We propose that the initial responses may be related to loss of descending inhibition of spinal reflexes but that plastic changes in the spinal cord is one of the mechanisms for the autonomic dysreflexia occurring 1 mo after injury.