Fiber-optic and articulating arm implementations of laminar optical tomography for clinical applications.
Fiber-optic and articulating arm implementations of laminar optical tomography for clinical applications.
复制标题
DOI：
10.1364/boe.1.000780
复制
发表时间：
2010-09-02
影响因子：
3.4
通讯作者：
Hillman EM
中科院分区：
文献类型：
--
作者：
Burgess SA;Ratner D;Chen BR;Hillman EM
层流光学层析成像（LOT）是近年来发展起来的一种吸收和荧光对比度深度分辨活体成像技术。到目前为止，LOT一直在台式配置中实施，限制了对组织的可访问性并限制了成像应用。在这里，我们报告了通过关节臂和光纤图像束实现的LOT，该光纤图像束允许灵活成像用于一系列临床应用。我们量化这两种实现的性能，通过成像的组织模仿幻影。
Laminar optical tomography (LOT) is a recently developed technique for depth-resolved in vivo imaging of absorption and fluorescence contrast. Until now, LOT has been implemented in a benchtop configuration, limiting accessibility to tissues and restricting imaging applications. Here we report on LOT implemented through an articulating arm and a fiber optic image bundle allowing flexible imaging for a range of clinical applications. We quantify the performance of these two implementations by imaging a tissue mimicking phantom.