Meiotic investigations of aneuploidy in the human.
Meiotic investigations of aneuploidy in the human.
复制标题
人类非整倍性的减数分裂研究。
DOI：
--
复制
发表时间：
1985
期刊：
影响因子：
--
通讯作者：
D. Cockburn
中科院分区：
文献类型：
--
作者：
M. Hultén;N. Saadallah;B. Wallace;D. Cockburn
人们普遍认为，在所有早期妊娠流产中，大约50%是染色体异常的，非整倍体孩子的出生给父母和社会带来了沉重的负担。非整倍体情况通常归因于卵子发生和精子发生过程中发生的两个减数分裂之一的非分离事件。人们的注意力主要集中在21三体条件上--出生时最常见的数字染色体异常。Juberg和Mowrey(24)在对唐氏综合征患者额外21号染色体亲本来源的多项研究中发现，%的病例归因于卵子发生过程中第一次减数分裂不分离，16%归因于第二次减数分裂不分离，12%归因于精子发生过程中第一次减数分裂不分离，8%归因于精子发生过程中第二次减数分裂不分离。
It is widely recognized that roughly 50% of all first trimester miscarriages are chromosomally abnormal and that the birth of an aneuploid child presents a heavy burden to parents and to society. The aneuploid condition is generally attributed to a nondisjunctional event at one of the two meiotic divisions which take place during oogenesis and spermatogenesis. Attention is largely focused on the trisomy 21 condition—the most common numerical chromosomal abnormality at birth. In a compilation of many studies into the parental origin of the extra chromosome 21 in individuals with Down syndrome assigned by Q-band polymorphism, Juberg and Mowrey (24) tound that 64% of cases were attributed to nondisjunction at the first meiotic division during oogenesis, 16% to nondisjunction at the second meiotic division during oogenesis, 12% to nondisjunction at the first meiotic division during spermatogenesis, and 8% to nondisjunction at the second meiotic division during spermatogenesis.
人类早期和中/晚期粗线期精母细胞的完整常染色体染色体图。
影响因子：
9.8
作者：
Jagiello,GM;Fang,JS
通讯作者：
Fang,JS