COVID-19-induced liver injury in adult patients: A brief overview.
COVID-19-induced liver injury in adult patients: A brief overview.
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COVID-19诱导的成年患者肝损伤：简短概述。
DOI：
10.5501/wjv.v11.i6.443
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发表时间：
2022-11-25
期刊：
影响因子：
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通讯作者：
Zeppieri, Marco
中科院分区：
文献类型：
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作者：
Grando, Martina;Balbi, Massimiliano;Zeppieri, Marco
自2019年以来，冠状病毒疾病在全球范围内传播，迄今造成了重要的大流行问题和各种社会健康问题。关于这种病毒的来源及其对肺外器官的影响，人们知之甚少。这种病毒的不同机制及其对人类的影响仍在研究中，希望找到治疗这种疾病的方法和与感染相关的病理机制。冠状病毒病2019(新冠肺炎)造成的肝脏损害有时被低估，在过去几年一直是重要的临床关注对象。肝功能障碍可以表现为不同的形式，有时是轻微的，没有特定的体征和症状，也可能是严重的，具有重要的临床意义。有几项研究试图解释病毒进入(嗜肝)肝细胞的机制以及病毒对这一重要器官的影响。目前的文献清楚地表明，肝损伤是新冠肺炎感染患者治疗中的一个重要临床方面，特别是在虚弱和合并疾病的患者中。我们简要综述的目的是总结目前有关新冠肺炎感染患者肝损伤的形式、并发症、病理机制、肝损伤的临床特征、合并症的影响和临床处理的文献。
Coronavirus disease has spread worldwide since 2019, causing important pandemic issues and various social health problems to date. Little is known about the origin of this virus and the effects it has on extra-pulmonary organs. The different mechanisms of the virus and the influence it has on humans are still being studied, with hopes of finding a cure for the disease and the pathologies associated with the infection. Liver damage caused by coronavirus disease 2019 (COVID-19) is sometimes underestimated and has been of important clinical interest in the past few years. Hepatic dysfunctions can manifest in different forms which can sometimes be mild and without specific signs and symptoms or be severe with important clinical implications. There are several studies that have tried to explain the mechanism of entry (hepatotropism) of the virus into hepatocytes and the effects the virus has on this important organ. What clearly emerges from the current literature is that hepatic injury represents an important clinical aspect in the management of patients infected with COVID-19, especially in frail patients and those with comorbidities. The aim of our brief overview is to summarize the current literature regarding the forms of hepatic damage, complications, mechanisms of pathology, clinical features of liver injury, influence of comorbidities and clinical management in patients with COVID-19 infection.