High phosphate diet increases arterial blood pressure via a parathyroid hormone mediated increase of renin
High phosphate diet increases arterial blood pressure via a parathyroid hormone mediated increase of renin
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DOI：
10.1097/hjh.0000000000000261
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发表时间：
2014-09-01
影响因子：
4.9
通讯作者：
Valdivielso, Jose M.
中科院分区：
文献类型：
--
作者：
Bozic, Milica;Panizo, Sara;Valdivielso, Jose M.
背景：越来越多的证据表明，磷酸盐摄入量与血压水平有关。然而，流行病学研究的数据显示出不一致的结果。方法与结果：本研究旨在评价高循环磷对健康大鼠动脉血压的影响，并探讨其可能的作用机制。饲喂高磷酸盐饲料4周的动物血压升高，在饲料中添加磷酸盐粘合剂（碳酸镧）后血压恢复正常。肾素在肾脏中的表达升高，血浆肾素活性升高，血管紧张素II （Ang II）水平升高，左心室肥厚。磷酸盐结合剂的加入减弱了肾素和Ang II水平的增加。喂食高磷酸盐饲料的动物甲状旁腺激素（PTH）水平也较高，当饲料中存在磷酸盐粘合剂时，甲状旁腺激素（PTH）水平下降。然而，血液中的P值仍然很高。第二组大鼠接受甲状旁腺切除术，并通过植入的微渗透泵持续输注生理水平的甲状旁腺激素。持续注射甲状旁腺激素的高磷酸盐饲料喂养的动物没有表现出血压升高，尽管血P水平升高。最后，与维拉帕米不同的是，在饮用水中加入氯沙坦后，喂食高磷酸盐食物的老鼠的血压回升。结论：本研究结果表明，高磷酸盐饮食通过PTH介导的肾素增加而增加动脉血压。
Background: There is growing evidence suggesting that phosphate intake is associated with blood pressure levels. However, data from epidemiological studies show inconsistent results.Method and results: The present study was designed to evaluate the effect of high circulating phosphorus on arterial blood pressure of healthy rats and to elucidate the potential mechanism that stands behind this effect. Animals fed a high phosphate diet for 4 weeks showed an increase in blood pressure, which returned to normal values after the addition of a phosphate binder (lanthanum carbonate) to the diet. The expression of renin in the kidney was higher, alongside an increase in plasma renin activity, angiotensin II (Ang II) levels and left ventricular hypertrophy. The addition of the phosphate binder blunted the increase in renin and Ang II levels. The levels of parathyroid hormone (PTH) were also higher in animals fed a high phosphate diet, and decreased when the phosphate binder was present in the diet. However, blood P levels remained elevated. A second group of rats underwent parathyroidectomy and received a continuous infusion of physiological levels of PTH through an implanted mini-osmotic pump. Animals fed a high phosphate diet with continuous infusion of PTH did not show an increase in blood pressure, although blood P levels were elevated. Finally, unlike with verapamil, the addition of losartan to the drinking water reverted the increase in blood pressure in rats fed a high phosphate diet.Conclusion: The results of this study suggest that a high phosphate diet increases arterial blood pressure through an increase in renin mediated by PTH.