Lactotripeptides intake and blood pressure management: A meta-analysis of randomised controlled clinical trials
Lactotripeptides intake and blood pressure management: A meta-analysis of randomised controlled clinical trials
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DOI：
10.1016/j.numecd.2013.02.006
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发表时间：
2013-05-01
影响因子：
3.9
通讯作者：
Zhang, W.
中科院分区：
文献类型：
--
作者：
Qin, L. -Q.;Xu, J. -Y.;Zhang, W.
背景和目标：乳三肽（LTP，包括IPP和VPP）在生活方式改变的框架内预防和控制高血压（心血管危险因素）方面有希望，因为据报道LTP对血管紧张素转换酶具有抑制作用。虽然测试LTP疗效的临床试验数量不断增加，但结果并不一致，特别是在过去几年中。本荟萃分析的目的是精确估计LTP对常规血压（BP）和24小时动态血压（ABP）的总体平均效应，以及与基线BP、种族和研究设计相关的BP变化，以更好地反映不断发展的领域。数据综合：在对24项研究（28项试验，1919例人类受试者）的一般分析中，收缩压（SBP）和舒张压（DBP）均小幅降低，合并平均效应为1.66（95%置信区间（CI）：-2.48和-0.84）和0.76 mmHg（-1.31和-0.20）。在对LTP干预的24小时ABP反应的分析中，SBP和DBP分别降低1.30（-2.49和0.11）和0.57 mmHg（-1.49和0.35）。在亚组分析中，抗高血压疗效似乎与基线BP，种族差异，治疗持续时间和双与非双盲design.Conclusions：目前的研究结果表明，BP降低LTP的效果是统计学上显着的，虽然幅度小。需要更多的临床研究（特别是ABP的随机双盲试验）来最终确定LTP的降压疗效。版权所有（C）2013 Elsevier B. V.保留所有权利。
Background and aims: Lactotripeptides (LTPs, including IPP and VPP) have held promise in the framework of lifestyle modification for prevention and control of hypertension - a cardiovascular risk factor, as LTPs are reported to have an inhibitory effect on angiotensin-converting enzyme. While the number of clinical trials to test the efficacy of LTP continues to increase, the results have been inconsistent, especially in the last few years. The purpose of the present meta-analysis is to precisely estimate the pooled mean effect of LTPs on conventional blood pressure (BP) generally and on 24-h ambulatory BP (ABP) particularly, as well as the change of BP in relation to baseline BP, race, and study design, to better reflect the evolving field.Data synthesis: In general analysis of 24 studies with 28 trials on 1919 human subjects, there are small reductions in both systolic BP (SBP) and diastolic BP (DBP) with the pooled mean effects of 1.66 (95% confidence interval (CI): -2.48 and -0.84) and 0.76 mmHg (-1.31 and -0.20) in response to LTP administration. In analysis of 24-h ABP response to LTP intervention, the reductions of SBP and DBP are 1.30 (-2.49 and -0.11) and 0.57 mmHg (-1.49 and 0.35). In subgroup analysis, the anti-hypertensive efficacy appears to be related to baseline BP, ethnic differences, treatment duration and double versus not double-blind design.Conclusions: The present findings indicate that the BP-lowering effect of LTP is statistically significant, though small in magnitude. More clinical investigations (especially randomized double-blind trials with ABP) are warranted to determine the anti-hypertensive efficacy of LTP conclusively. Copyright (C) 2013 Elsevier B.V. All rights reserved.