Efflux-mediated drug resistance in bacteria: an update.
Efflux-mediated drug resistance in bacteria: an update.
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DOI：
10.2165/11317030-000000000-00000
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发表时间：
2009-08-20
期刊：
影响因子：
11.5
通讯作者：
Nikaido H
中科院分区：
文献类型：
--
作者：
Li XZ;Nikaido H
药物外排泵在细菌的耐药性中起着关键作用，还具有其他功能。以人类、动物、植物和环境来源的细菌为特征的多药和药物特异性外排泵的名单越来越多。这些泵大部分是在染色体上编码的，尽管它们也可以是质粒编码的。以前的一篇文章(李新忠和日本H，药物，2004；[2]：159-204)对外排介导的细菌耐药性进行了全面的综述。在过去的五年里，对耐药相关外排转运蛋白的进一步了解取得了重大进展，本文就2003年以来这一领域的最新研究进展作一综述。这在多个方面得到了证实，包括但不限于：对已知的药物外排泵进行进一步的分子和生物化学表征，鉴定新型药物外排泵；阐明药物转运体的运输机制；药物外排泵的调节机制；确定药物外排泵在应激反应、毒性和细胞通讯等其他功能中的作用；以及外排泵抑制剂的开发。总体而言，药物外排转运体的多方面影响需要新的策略来对抗细菌的多药耐药性。
Drug efflux pumps play a key role in drug resistance and also serve other functions in bacteria. There has been a growing list of multidrug and drug-specific efflux pumps characterized from bacteria of human, animal, plant and environmental origins. These pumps are mostly encoded on the chromosome although they can also be plasmid-encoded. A previous article (Li X-Z and Nikaido H, Drugs, 2004; 64[2]: 159–204) had provided a comprehensive review regarding efflux-mediated drug resistance in bacteria. In the past five years, significant progress has been achieved in further understanding of drug resistance-related efflux transporters and this review focuses on the latest studies in this field since 2003. This has been demonstrated in multiple aspects that include but are not limited to: further molecular and biochemical characterization of the known drug efflux pumps and identification of novel drug efflux pumps; structural elucidation of the transport mechanisms of drug transporters; regulatory mechanisms of drug efflux pumps; determining the role of the drug efflux pumps in other functions such as stress responses, virulence and cell communication; and development of efflux pump inhibitors. Overall, the multifaceted implications of drug efflux transporters warrant novel strategies to combat multidrug resistance in bacteria.
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