Clinical usefulness of haptoglobin levels to evaluate hemolysis in recently transfused patients.
Clinical usefulness of haptoglobin levels to evaluate hemolysis in recently transfused patients.
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DOI：
10.1155/2011/389854
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发表时间：
2011
影响因子：
--
通讯作者：
Forte F
中科院分区：
文献类型：
--
作者：
Gupta S;Ahern K;Nakhl F;Forte F
导论.结合珠蛋白结合游离血红蛋白的珠蛋白部分。血清结合珠蛋白测量被用作诊断溶血性贫血的实验室标志物。由于储存的血液含有游离血红蛋白，输血可能会影响触珠蛋白水平。研究目的。本研究的目的是评估是否可以测量血清结合珠蛋白，以评估最近输血患者的溶血。患者和方法。21例患者，接受超过一个单位的浓缩红细胞（PRBC）的假定非溶血适应症，入组。在输血前、输血后即刻、输血后24小时和48小时记录血清触珠蛋白水平。观察和结果。重复测量的方差分析用于检查不同时间段的血清结合珠蛋白水平，未发现显著差异（P = 0.28）。结论结果表明，血清结合珠蛋白可用于诊断接受多单位PRBC的患者的溶血。
Introduction. Haptoglobin binds the globin portion of free hemoglobin. Serum haptoglobin measurement is used as a laboratory marker for the diagnosis of hemolytic anemia. Since stored blood contains free hemoglobin, transfusion may affect haptoglobin levels. Study Objectives. The aim of the study was to evaluate whether serum haptoglobin could be measured to assess hemolysis in recently transfused patients. Patients and Methods. Twenty-one patients, receiving more than one unit of packed red blood cells (PRBCs) for presumed nonhemolytic indications, were enrolled. Serum haptoglobin levels were recorded before, immediately after, and 24 and 48 hours after transfusion. Observations and Results. Analysis of variance with a repeated measures was used to examine the serum haptoglobin levels at different time periods and no significant difference was found (P = .28). Conclusion. The results suggest that serum haptoglobin can be used in the diagnosis of hemolysis in patients receiving multiple units of PRBC.