Mapping cortical change across the human life span
Mapping cortical change across the human life span
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DOI：
10.1038/nn1008
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发表时间：
2003-03-01
影响因子：
25
通讯作者：
Toga, AW
中科院分区：
文献类型：
--
作者：
Sowell, ER;Peterson, BS;Toga, AW
我们使用磁共振成像和皮质匹配算法来绘制176名年龄从7岁到87岁的正常人的灰质密度（GMD）。我们发现一个显着的，非线性下降，GMD随着年龄的增长，这是最快的7至约60岁之间，在背侧额叶和顶叶联合皮质的外侧和半球间的表面。年龄效应在左后颞区被逆转，GMD增加持续到30岁，然后迅速下降。成熟和衰老效应的轨迹在皮层上变化很大。视觉、听觉和边缘皮质的髓鞘形成较早，与额叶和顶叶新皮质相比，它们的髓鞘形成会持续到成年期。我们的研究结果还表明，后颞叶皮质，主要是在左半球，通常支持语言功能，有一个更长的过程中的成熟比任何其他皮质区域。
We used magnetic resonance imaging and cortical matching algorithms to map gray matter density (GMD) in 176 normal individuals ranging in age from 7 to 87 years. We found a significant, nonlinear decline in GMD with age, which was most rapid between 7 and about 60 years, over dorsal frontal and parietal association cortices on both the lateral and interhemispheric surfaces. Age effects were inverted in the left posterior temporal region, where GMD gain continued up to age 30 and then rapidly declined. The trajectory of maturational and aging effects varied considerably over the cortex. Visual, auditory and limbic cortices, which are known to myelinate early, showed a more linear pattern of aging than the frontal and parietal neocortices, which continue myelination into adulthood. Our findings also indicate that the posterior temporal cortices, primarily in the left hemisphere, which typically support language functions, have a more protracted course of maturation than any other cortical region.