Iron regulator hepcidin exhibits antiviral activity against hepatitis C virus.
Iron regulator hepcidin exhibits antiviral activity against hepatitis C virus.
复制标题
DOI：
10.1371/journal.pone.0046631
复制
发表时间：
2012
期刊：
影响因子：
3.7
通讯作者：
Liu C
中科院分区：
文献类型：
--
作者：
Liu H;Trinh TL;Dong H;Keith R;Nelson D;Liu C
Hepatitis C viral infection affects 170 million people worldwide. It causes serious chronic liver diseases. HCV infection has been implicated in iron accumulation in the liver and iron overload has been shown to be a potential cofactor for HCV associated hepatocellular carcinoma progression. The underlying mechanisms are not understood. Human hepcidin, a 25 amino acid peptide mainly produced by hepatocytes, is a key regulator of iron metabolism. Alteration of hepcidin expression levels has been reported in the setting of chronic HCV infection and hepatocellular carcinoma. In this study, we aim to examine the interactions between HCV infection and hepcidin expression in liver cells. We found that hepcidin expression was suppressed in HCV infected cells. The suppressive effect appears to be regulated by histone acetylation but not DNA methylation. Moreover, we found that hepcidin had a direct antiviral activity against HCV replication in cell culture. The antiviral effect is associated with STAT3 activation. In conclusion, hepcidin can induce intracellular antiviral state while HCV has a strategy to suppress hepcidin expression. This may be a novel mechanism by which HCV circumvents hepatic innate antiviral defense.
登录
查看更多内容
影响因子：
5
作者：
Lukavsky, Peter J.
通讯作者：
Lukavsky, Peter J.
影响因子：
46.9
作者：
Judge, AD;Sood, V;MacLachlan, I
通讯作者：
MacLachlan, I
影响因子：
4.8
作者：
Lauth, X;Babon, JJ;Westerman, ME
通讯作者：
Westerman, ME
影响因子：
5.4
作者：
Nairz, Manfred;Fritsche, Gernot;Weiss, Guenter
通讯作者：
Weiss, Guenter
影响因子：
20.3
作者：
Falzacappa, Maria Vittoria Verga;Spasic, Maja Vujic;Muckenthaler, Martina U.
通讯作者：
Muckenthaler, Martina U.