[Psychiatric sequelae of interferon-alpha therapy].
[Psychiatric sequelae of interferon-alpha therapy].
复制标题
[干扰素-α治疗的精神后遗症]。
作者：
A. Kovács;Á. Szomor;I. Ábrahám;F. Nagy;H. Losonczy
介绍
精神病理条件通常使干扰素α的治疗复杂化。其中最重要的是抑郁症，它可以诱发自杀企图。干扰素-α的精神副作用的结果需要停止治疗，在更严重的情况下，需要精神治疗。
目的和方法
一个简短的文献综述介绍了α干扰素的生物学，重点是中枢神经系统的影响，这可能是密切相关的精神副作用。三个病例报告表明干扰素诱导的精神疾病的跨学科性质。
结果
干扰素-α的神经精神副作用的出现是频繁的，其后果可以证明是戏剧性的：参与重要的预后，精神病发病率，特别是抑郁症，和自杀风险。
结论
从治疗前评估到后续护理，临床医生和精神科医生的密切合作是必要的。
INTRODUCTION
Psychopathologic conditions commonly complicate the treatment with the interferon-alpha. The most important among them is depression, which can induce suicidal attempt. The outcome of mental side effects of interferon-alpha necessitate the discontinuation of therapy and, in more severe cases, psychiatric treatment.
AIM AND METHOD
A brief literature review presents the biology of interferon-alpha with emphasis on the central nervous system effects which are probably closely related to mental side effects. Three case reports demonstrate the interdisciplinary nature of interferon induced psychiatric conditions.
RESULTS
The appearance of neuropsychiatric side effects of interferon-alpha are frequent, the consequences of which can prove dramatic: involvement of the vital prognosis, psychiatric morbidity, especially depressions, and suicidal risk.
CONCLUSION
The close collaboration of clinical practitioners and psychiatrists, from the pre-therapeutical evaluation to the follow up care is required.