ANGIOGENESIS BY HUMAN-MELANOMA AND BREAST-CANCER CELLS
ANGIOGENESIS BY HUMAN-MELANOMA AND BREAST-CANCER CELLS
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DOI：
10.1016/0304-3835(80)90127-5
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发表时间：
1980-01-01
期刊：
影响因子：
9.7
通讯作者：
NORDQUIST, RE
中科院分区：
文献类型：
--
作者：
CHAUDHURY, TK;LERNER, MP;NORDQUIST, RE
The induction of new vasculature is essential for tumor growth and survival. Through studies of the angiogenic properties of human breast cancer and melanoma cell lines by implantation in rabbit cornea, results show that breast tumor and melanoma cells produce an angiogenic factor. Melanoma cells had approximately twice the activity of breast tumor cells. Initiation of angiogenesis by 1 .times. 106 melanoma cells occurred in 3 days, reached maximum at 7 days and resolved in 21 days. Implantation of 2 .times. 106 breast tumor cells initiated angiogenesis in 6 days, reached maximum in 10 days and resolved in 24 days. The difference in the time of angiogenic induction may be related to the aggressiveness of each tumor type.
