Duration and death in systemic lupus erythematosus. An analysis of 249 cases.
Duration and death in systemic lupus erythematosus. An analysis of 249 cases.
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DOI：
10.1001/jama.1974.03230250023021
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发表时间：
1974-03
期刊：
影响因子：
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通讯作者：
E. Dubois;M. Wierzchowiecki;M. Cox;J. Weiner
中科院分区：
文献类型：
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作者：
E. Dubois;M. Wierzchowiecki;M. Cox;J. Weiner
在491例系统性红斑狼疮（SLE）患者中，已知死亡249例（51%）。从1950年至1955年，57例患者中有15例（26%）死于中枢神经系统（CNS）损害，同等数量的患者死于尿毒症。1956年开始使用高剂量皮质类固醇治疗中枢神经系统受累。从1956年至1962年，100例患者中只有11例死于中枢神经系统受累，36%的患者死于尿毒症。在过去的十年中，大剂量皮质类固醇治疗，透析和肾移植，只有7/92（8%）的患者死于中枢神经系统损害，14%的患者死于尿毒症。感染、血管并发症和恶性肿瘤导致的死亡发生率更高。这些变化是显著的（P黑人患者没有比其他人更恶性的过程。79名黑人患者从诊断到死亡的中位时间为3.5年，其他170名患者的中位时间相同。
Of 491 patients with systemic lupus erythematosus (SLE), 249 (51%) are known dead. From 1950 to 1955, 15 of 57 patients (26%) died of central nervous system (CNS) damage and an equal number died of uremia. High-dosage corticosteroid therapy for CNS involvement was introduced in 1956. From 1956 to 1962, only 11 of 100 patients died of CNS involvement and 36% of the patients died of uremia. During the past ten years, with high-dose corticosteroid therapy, dialysis, and renal transplantation, only 7 of 92 patients (8%) died of CNS damage and 14% of the patients died of uremia. Death from infections, vascular complications, and malignant neoplasms occurred more frequently. The changes were significant ( P Black patients did not have a more malignant course than others. The median time from diagnosis to death in 79 blacks was 3.5 years; this was identical in 170 other patients.