Effects of tooth loss on brain structure: a voxel-based morphometry study
Effects of tooth loss on brain structure: a voxel-based morphometry study
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DOI：
10.1016/j.jpor.2017.12.007
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发表时间：
2018-07-01
影响因子：
3.6
通讯作者：
Kondo, Hisatomo
中科院分区：
文献类型：
--
作者：
Kobayashi, Takuya;Kubota, Masafumi;Kondo, Hisatomo
目的：超老龄化社会最突出的问题之一是痴呆症患者的快速增加。牙科的横断面研究表明，与健康人相比，痴呆症患者的口腔健康状况更差。本研究的目的是澄清牙齿缺失对大脑结构的影响，通过比较无牙和有牙的subjects.Methods：主题被招募从岩手医科大学医院牙科中心的Dongshan诊所的灰质（GM）和白色物质（WM）的体积。对无牙（5名男性，8名女性，81.8 +/- 1.24岁）和有牙受试者（4名男性，7名女性，77.1 +/- 4.25岁）进行实验。痴呆患者被排除在本研究之外。以颅内体积、年龄、性别和高血压史为协变量，比较无牙颌和有牙颌受试者的GM和WM脑体积。分析的大脑区域被确定由蒙特利尔神经研究所坐标转化为无牙Subjects.Results的解剖坐标：WM结构图像的分析发现无牙和无牙科目之间的形态差异。然而，在海马，尾状核和颞极的右半球在缺牙subjects.Conclusions：这项研究的结果表明，牙齿损失是一个因果关系的体积减少的大脑区域相关的记忆，学习和认知萎缩的GM。(C)2018日本口腔修复学会。由爱思唯尔有限公司出版。保留所有权利。
Purpose: One of the most prominent issues in a super-aging society is the rapid increase in dementia patients. Cross-sectional studies in dentistry have indicated that patients with dementia have worse oral health compared to healthy people. The purpose of this study was to clarify the influence of tooth loss on brain structure by comparing the volumes of gray matter (GM) and white matter (WM) between edentulous and dentulous subjects.Methods: Subjects were recruited from the Denture Clinic at Iwate Medical University Hospital Dental Center. Experiments were performed on edentulous (5 males, 8 females, 81.8 +/- 1.24 years) and dentulous subjects (4 males, 7 females, 77.1 +/- 4.25 years). Patients with dementia were excluded from this study. Brain volumes of GM and WM in edentulous and dentulous subjects were compared using intracranial volume, age, gender and history of hypertension as covariates. Analyzed brain areas were identified by transforming the Montreal Neurological Institute coordinate into the anatomical coordinate in edentulous subjects.Results: The analysis of WM structural images found no morphological differences between dentulous and edentulous subjects. However, significant atrophy of GM was observed in the hippocampus, caudate nucleus and temporal pole of the right hemisphere in edentulous subjects.Conclusions: The results of this study suggest that tooth loss was a causal factor for volume reduction in brain areas related to memory, learning and cognition. (C) 2018 Japan Prosthodontic Society. Published by Elsevier Ltd. All rights reserved.