O-GlcNAcylation and the Metabolic Shift in High-Proliferating Cells: All the Evidence Suggests that Sugars Dictate the Flux of Lipid Biogenesis in Tumor Processes.
O-GlcNAcylation and the Metabolic Shift in High-Proliferating Cells: All the Evidence Suggests that Sugars Dictate the Flux of Lipid Biogenesis in Tumor Processes.
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DOI：
10.3389/fonc.2016.00006
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发表时间：
2016
影响因子：
4.7
通讯作者：
Lefebvre T
中科院分区：
文献类型：
--
作者：
Baldini SF;Lefebvre T
癌细胞的特点是具有高增殖能力。这加速了膜化合物的生物合成，以满足增加分裂细胞膜表面和重塑脂质微区结构的需要。最近，人们开始关注癌细胞中观察到的 O-GlcNAc 酰化过程的上调。尽管文献中描述了脂肪生成转录调节因子的 O-GlcNAc 酰化（例如 FXR、LXR、ChREBP），但对于驱动脂肪生成的酶（乙酰辅酶 A 羧化酶和脂肪酸合酶 (FAS)）的调节知之甚少。 FAS 和 O-GlcNAc 转移酶 (OGT) 在癌细胞中的表达和催化活性都很高，但这两种酶的相互调节仍未被探索。从这个角度来看，我们收集了连接 FAS 和 OGT 的数据，从而为探索这两个在肿瘤生长中发挥核心作用的角色的复杂功能铺平了道路。
Cancer cells are characterized by their high capability to proliferate. This imposes an accelerated biosynthesis of membrane compounds to respond to the need for increasing the membrane surface of dividing cells and remodeling the structure of lipid microdomains. Recently, attention has been paid to the upregulation of O-GlcNAcylation processes observed in cancer cells. Although O-GlcNAcylation of lipogenic transcriptional regulators is described in the literature (e.g., FXR, LXR, ChREBP), little is known about the regulation of the enzymes that drive lipogenesis: acetyl co-enzyme A carboxylase and fatty acid synthase (FAS). The expression and catalytic activity of both FAS and O-GlcNAc transferase (OGT) are high in cancer cells but the reciprocal regulation of the two enzymes remains unexplored. In this perspective, we collected data linking FAS and OGT and, in so doing, pave the way for the exploration of the intricate functions of these two actors that play a central role in tumor growth.