ILAE Official Report: A practical clinical definition of epilepsy
ILAE Official Report: A practical clinical definition of epilepsy
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DOI：
10.1111/epi.12550
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发表时间：
2014-04-01
期刊：
影响因子：
5.6
通讯作者：
Wiebe, Samuel
中科院分区：
文献类型：
--
作者：
Fisher, Robert S.;Acevedo, Carlos;Wiebe, Samuel
癫痫在2005年被概念性地定义为以产生癫痫发作的持久倾向为特征的大脑紊乱。这一定义通常适用于两次间隔> 24小时的无端癫痫发作。国际抗癫痫联盟（ILAE）接受了一个工作组的建议，修改了不符合两个无端癫痫发作标准的特殊情况的实际定义。特别工作组建议，癫痫被认为是一种大脑疾病，定义为以下任何条件：（1）至少两个无端（或反射性）发作间隔> 24小时;（2）1次无诱因发作（或反射性）癫痫发作和进一步癫痫发作的概率与一般复发风险相似（至少60%）在未来10年内发生两次无端癫痫发作后;（3）诊断为癫痫综合征。对于患有年龄依赖性癫痫综合征但现在已超过适用年龄或在过去10年内无癫痫发作且至少在过去5年内停用抗癫痫药物的患者，癫痫被认为已消退。“已解决”不一定等同于传统的“缓解”或“治愈”。“不同的实际定义可用于各种具体目的。修订后的癫痫定义使该术语与常用术语保持一致。总结本文的PowerPoint幻灯片可在支持信息部分下载。
Epilepsy was defined conceptually in 2005 as a disorder of the brain characterized by an enduring predisposition to generate epileptic seizures. This definition is usually practically applied as having two unprovoked seizures >24h apart. The International League Against Epilepsy (ILAE) accepted recommendations of a task force altering the practical definition for special circumstances that do not meet the two unprovoked seizures criteria. The task force proposed that epilepsy be considered to be a disease of the brain defined by any of the following conditions: (1) At least two unprovoked (or reflex) seizures occurring >24h apart; (2) one unprovoked (or reflex) seizure and a probability of further seizures similar to the general recurrence risk (at least 60%) after two unprovoked seizures, occurring over the next 10years; (3) diagnosis of an epilepsy syndrome. Epilepsy is considered to be resolved for individuals who either had an age-dependent epilepsy syndrome but are now past the applicable age or who have remained seizure-free for the last 10years and off antiseizure medicines for at least the last 5years. "Resolved" is not necessarily identical to the conventional view of "remission or "cure." Different practical definitions may be formed and used for various specific purposes. This revised definition of epilepsy brings the term in concordance with common use.A PowerPoint slide summarizing this article is available for download in the Supporting Information section .