Association between psoriasis and the metabolic syndrome
Association between psoriasis and the metabolic syndrome
复制标题
DOI：
10.1159/000111512
复制
发表时间：
2008-01-01
期刊：
影响因子：
3.4
通讯作者：
Meyerovitch, J.
中科院分区：
文献类型：
--
作者：
Cohen, A. D.;Sherf, M.;Meyerovitch, J.
背景：以前的报道显示炎症性疾病如系统性红斑狼疮或类风湿关节炎与代谢综合征之间存在关联。最近的数据表明，牛皮癣是一种炎症性疾病，提示牛皮癣可能是代谢综合征的组成部分之一。目的：探讨银屑病与代谢综合征的关系。方法：利用克拉利特卫生服务的数据库进行横断面研究。病例患者定义为诊断为寻常型牛皮癣的患者。对照从Clalit健康服务注册者名单中随机选择。通过单因素分析比较病例和对照患者代谢综合征（缺血性心脏病、高血压、糖尿病、肥胖和血脂异常）组成部分的比例。采用X-2检验比较各组间的分类参数。Logistic和线性回归模型用于测量银屑病与代谢综合征之间的关联。结果：该研究包括16851例牛皮癣患者和48681例对照。病例组中男性8449例（50.1%），女性8402例（49.9%），平均年龄42.7岁（SD = 20.3，范围= 2-111）。13.8%的银屑病患者存在糖尿病，而对照组为7.3% (p ！0.001)。银屑病患者中高血压发生率为27.5%，对照组为14.4% (p ！0.001)。8.4%的牛皮癣患者存在肥胖，而对照组为3.6% (p ！0.001)。14.2%的银屑病患者出现缺血性心脏病，而对照组为7.1% (p ！0.001)。调整患者年龄、性别和吸烟状况的多变量模型显示，银屑病与代谢综合征（OR = 1.3, 95% CI = 1.1-1.4）、缺血性心脏病（OR = 1.1, 95% CI = 1.0-1.2）、糖尿病（OR = 1.2, 95% CI = 1.0-1.3）、高血压（OR = 1.3, 95% CI = 1.2-1.5）和肥胖（OR = 1.7, 95% CI = 1.5-1.9）相关。局限性：该研究设计为病例对照研究，因此仅证明了关联而非因果关系。结论：我们的研究结果表明银屑病与代谢综合征之间可能存在关联。适当治疗代谢综合征可能是银屑病患者管理的重要组成部分。版权所有(c) 2008 S. Karger AG，巴塞尔。
Background: Previous reports have shown an association between inflammatory diseases such as systemic lupus erythematosus or rheumatoid arthritis and the metabolic syndrome. Recent data demonstrate that psoriasis is an inflammatory disease, suggesting that psoriasis may be one of the components of the metabolic syndrome. Objective: To assess the association between psoriasis and the metabolic syndrome. Methods: A cross-sectional study was performed utilizing the database of the Clalit Health Services. Case patients were defined as patients with a diagnosis of psoriasis vulgaris. Controls were randomly selected from the list of Clalit Health Services enrollees. The proportions of components of the metabolic syndrome ( ischemic heart disease, hypertension, diabetes, obesity and dyslipidemia) were compared between case and control patients by univariate analyses. X-2 tests were used to compare categorical parameters between the groups. Logistic and linear regression models served to measure the association between psoriasis and the metabolic syndrome. Results: The study included 16,851 patients with psoriasis and 48,681 controls. In the case group, there were 8,449 men (50.1%) and 8,402 women (49.9%), with a mean age of 42.7 years (SD = 20.3, range = 2-111). Diabetes mellitus was present in 13.8% of the patients with psoriasis as compared to 7.3% of the controls ( p ! 0.001). Hypertension occurred in 27.5% of the patients with psoriasis and in 14.4% of the controls ( p ! 0.001). Obesity was present in 8.4% of the patients with psoriasis as opposed to 3.6% of the controls ( p ! 0.001). Ischemic heart disease was observed in 14.2% of the patients with psoriasis as compared to 7.1% of the controls ( p ! 0.001). Multivariate models adjusting for age, gender and smoking status of the patients demonstrated that psoriasis was associated with the metabolic syndrome (OR = 1.3, 95% CI = 1.1-1.4), ischemic heart disease ( OR = 1.1, 95% CI = 1.0-1.2), diabetes mellitus (OR = 1.2, 95% CI = 1.0-1.3), hypertension (OR = 1.3, 95% CI = 1.2-1.5) and obesity ( OR = 1.7, 95% CI = 1.5-1.9). Limitations: The study is designed as a case-control study, thus an association alone was proven and not causality. Conclusion: Our findings demonstrate a possible association between psoriasis and the metabolic syndrome. Appropriate treatment of the metabolic syndrome may be an important part of the management of patients with psoriasis. Copyright (c) 2008 S. Karger AG, Basel.