A public-private partnership to unlock the untargeted kinome
A public-private partnership to unlock the untargeted kinome
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DOI：
10.1038/nchembio.1113
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发表时间：
2013-01-01
影响因子：
14.8
通讯作者：
Zuercher, William J.
中科院分区：
文献类型：
--
作者：
Knapp, Stefan;Arruda, Paulo;Zuercher, William J.
迫切需要化学探针来功能性地注释迄今为止未靶向的激酶，并刺激新药发现努力以解决未满足的医疗需求。人激酶组的大小与探针产生相关的高成本相结合，严重限制了获得新探针。我们建议采用大规模公私伙伴关系作为一种新的办法，这种办法可提供规模经济、最大限度地减少冗余以及分担风险和费用。
Chemical probes are urgently needed to functionally annotate hitherto-untargeted kinases and stimulate new drug discovery efforts to address unmet medical needs. The size of the human kinome combined with the high cost associated with probe generation severely limits access to new probes. We propose a large-scale public-private partnership as a new approach that offers economies of scale, minimized redundancy and sharing of risk and cost.