Myelin imaging compound (MIC) enhanced magnetic resonance imaging of myelination.
Myelin imaging compound (MIC) enhanced magnetic resonance imaging of myelination.
复制标题
髓磷脂成像化合物 (MIC) 增强了髓鞘形成的磁共振成像。
DOI：
10.1021/jm201010e
复制
发表时间：
2012
影响因子：
7.3
通讯作者：
Wang,Yanming
中科院分区：
文献类型：
--
作者：
Frullano,Luca;Zhu,Junqing;Wang,Changning;Wu,Chunying;Miller,RobertH;Wang,Yanming
脊椎动物神经系统的特点是髓鞘形成，这是保护轴突和促进电脉冲转导的基本生物过程。髓鞘损伤被认为是多发性硬化症(MS)等自身免疫性疾病的主要影响。目前，治疗干预的重点是保护髓鞘完整性和促进髓鞘修复。这些努力需要伴随着一种有效的成像工具，该工具可以将疾病进展与髓鞘形成的程度联系起来。到目前为止，磁共振成像(MRI)是检测MS脑部病变的主要成像技术，但常规MRI无法区分脱髓鞘病变和其他炎症性病变，因此无法预测MS的疾病进展。为了解决这个问题，我们制备了一种基于Gd的造影剂，称为MIC(髓鞘成像化合物)，它与髓鞘结合具有高度的特异性。在这项工作中，我们证明了MIC具有很高的动力学稳定性和良好的驰豫特性。用MIC对大鼠脑室内注射后的髓鞘进行活体成像。发现MIC优先分布在高髓鞘区域，并能够检测到局灶性脱髓鞘区域。
The vertebrate nervous system is characterized by myelination, a fundamental biological process that protects the axons and facilitates electric pulse transduction. Damage to myelin is considered a major effect of autoimmune diseases such as multiple sclerosis (MS). Currently, therapeutic interventions are focused on protecting myelin integrity and promoting myelin repair. These efforts need to be accompanied by an effective imaging tool that correlates the disease progression with the extent of myelination. To date, magnetic resonance imaging (MRI) is the primary imaging technique to detect brain lesions in MS. However, conventional MRI cannot differentiate demyelinated lesions from other inflammatory lesions and therefore cannot predict disease progression in MS. To address this problem, we have prepared a Gd-based contrast agent, termed MIC (myelin imaging compound), which binds to myelin with high specificity. In this work, we demonstrate that MIC exhibits a high kinetic stability toward transmetalation with promising relaxometric properties. MIC was used for in vivo imaging of myelination following intracerebroventricular infusion in the rat brain. MIC was found to distribute preferentially in highly myelinated regions and was able to detect regions of focally induced demyelination.