NO INFLUENCE OF ADRENALECTOMY ON MEASURES OF TASTE SENSITIVITY IN THE RAT
NO INFLUENCE OF ADRENALECTOMY ON MEASURES OF TASTE SENSITIVITY IN THE RAT
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DOI：
10.1016/0031-9384(89)90354-5
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发表时间：
1989-10-01
影响因子：
2.9
通讯作者：
DOTY, RL
中科院分区：
文献类型：
--
作者：
BROSVIC, GM;RISSER, JM;DOTY, RL
采用高精度味觉测量法、计算机控制的go/no-go操作程序和非参数信号检测措施，研究肾上腺切除术对Long-Evans大鼠对氯化钠和蔗糖味觉敏感性和反应性的影响。与基线水平相比，肾上腺切除大鼠血浆皮质酮水平下降了328%，而氯化钠和水消耗分别增加了548%和165%。同样的措施在假手术的动物中保持不变。肾上腺切除和假手术动物对氯化钠和蔗糖的味觉敏感性和反应性没有差异，对氯化钠和蔗糖的辨别能力在肾上腺切除和假手术动物之间没有差异，辨别能力在两组之间也保持不变。目前的结果支持并扩展了先前的发现，即肾上腺切除术和由此产生的皮质类固醇缺乏不会影响大鼠的味觉敏感性或反应性。
The influence of adrenalectomy on the taste sensitivity and responsivity of Long-Evans rats to sodium chloride and sucrose tastants presented separately and in mixtures was examined using high precision gustometry, computer-controlled go/no-go operant procedures, and nonparametric signal detection measures. Relative to baseline levels, adrenalectomized rats'' plasma corticosterone levels decreased by 328% while sodium chloride and water consumption increased by 548% and 165%, respectively. The same measures remained unchanged in sham-operated animals. Taste sensitivity and responsitivity to sodium chloride and sucrose did not differ between adrenalectomized and sham-operated animals and discrimination performance to sodium chloride and sucrose did not differ between adrenalectomized and sham-operated animals and discrimination performance remained the same between the groups as well. The present results support and extend previous findings that adrenalectomy and the resultant corticosteroid deficiency does not influence taste sensitivity or responsivity in the rat.