Human γδ T cells:: a nonredundant system in the immune-surveillance against cancer
Human γδ T cells:: a nonredundant system in the immune-surveillance against cancer
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DOI：
10.1016/s1471-4906(01)02110-x
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发表时间：
2002-01-01
影响因子：
16.8
通讯作者：
Zocchi, MR
中科院分区：
文献类型：
--
作者：
Ferrarini, M;Ferrero, E;Zocchi, MR
在肿瘤进展过程中经常观察到MHC等位基因以及肿瘤特异性抗原表达的下调，导致MHC限制性、非T细胞介导的肿瘤特异性免疫受损。鉴于识别的抗原的独特集合和对经典抗原呈递分子的缺乏要求，因此，γ δ T细胞可能代表抗癌监视中的非冗余系统，如针对病原体的免疫应答所提出的。最近在小鼠中已经提供了γ δ和γ δ T细胞对抗癌监测做出独特贡献的证据。在此，我们讨论了常驻Vdelta1（+）和循环Vdelta2（+）T细胞在防御实体瘤和血液恶性肿瘤中的潜在作用。
Down-regulation of expression of MHC alleles, as well as tumor-specific antigens, is observed frequently during tumor progression, resulting in an impairment of MHC-restricted, alphabeta-T-cell-mediated, tumor-specific immunity. Given the unique set of antigens recognized and the lack of requirement for classical antigen-presenting molecules, gammadeltaT cells might, therefore, represent a nonredundant system in anticancer surveillance, as proposed for the immune response against pathogens. Evidence that gammadelta and alphabetaT cells make distinct contributions to anticancer surveillance has been provided recently in mice. Here, we discuss the potential role played by resident Vdelta1(+) and circulating Vdelta2(+) T cells in the defense against solid tumors and hematological malignancies.