Bovine achondrogenesis: evidence for defective chondrocyte differentiation.
Bovine achondrogenesis: evidence for defective chondrocyte differentiation.
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牛软骨形成：软骨细胞分化缺陷的证据。
DOI：
10.1016/8756-3282(87)90019-6
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发表时间：
1987
期刊：
影响因子：
4.1
通讯作者：
Ahmed,S
中科院分区：
文献类型：
--
作者：
Horton,WA;Jayo,MJ;Leipold,HW;Machado,MA;Campbell,D;Ahmed,S
一项关于牛骨发育不良中生长软骨异常的调查研究显示，荷斯坦牛中的一种称为斗牛犬小牛的疾病与人类软骨发育不全II型非常相似。在斗牛犬软骨中检测到大量的I型胶原蛋白和其他非II型胶原蛋白，所述斗牛犬软骨主要由广泛的血管管和细胞组成，所述细胞具有通常在生长板中发现的肥大和退行性软骨细胞的特征。有人提出，整个斗牛犬生长软骨的软骨细胞过早分化成肥大细胞，肥大细胞退化并使软骨易于血管侵入和软骨管的形成。这些管的存在可能是大多数观察到的胶原蛋白异常的原因。
A survey study of growth cartilage abnormalities in bovine bone dysplasias revealed that a disorder in Holstein cattle called bulldog calf closely resembles human achondrogenesis Type II. Substantial amounts of Type I collagen and other non Type II collagens were detected in the bulldog cartilage which was comprised primarily of extensive vascular canals and cells having the characteristics of hypertrophic and degenerative chondrocytes normally found in the growth plate. It is proposed that chondrocytes throughout the bulldog growth cartilage prematurely differentiate into hypertrophic cells that degenerate and predispose the cartilage to vascular invasion and the formation of cartilage canals. The presence of these canals probably accounts for most of the observed collagen abnormalities.