Regulation of the Cell Cycle in Normal and Pathological Glia
Regulation of the Cell Cycle in Normal and Pathological Glia
复制标题
DOI：
10.1177/107385840200800205
复制
发表时间：
2002-04
期刊：
影响因子：
--
通讯作者：
B. Stevens;R. Douglas Fields
中科院分区：
文献类型：
--
作者：
B. Stevens;R. Douglas Fields
胶质细胞周期的精确调控在神经系统发育和损伤反应中至关重要，而细胞周期控制的破坏与恶性胶质肿瘤和其他神经系统疾病有关。Ras信号通路在调节哺乳动物细胞周期中起着核心作用，不受控制的Ras信号通路与包括恶性胶质瘤在内的多种人类癌症有关。最近对神经胶质细胞的研究表明，Ras的激活可以通过影响细胞周期调节蛋白的下游信号通路之间的复杂相互作用诱导或抑制细胞增殖。在雪旺细胞中的研究已经开始描绘Ras在正常和病理胶质细胞中调节细胞周期的途径，并确定了治疗PNS和CNS恶性胶质肿瘤的有希望的治疗干预靶点。
Precise regulation of the glial cell cycle is essential during nervous system development and in response to injury, whereas disruption of cell cycle control is associated with malignant glial tumors and other nervous system diseases. The Ras signaling pathway plays a central role in regulating the mammalian cell cycle, and uncontrolled Ras signaling has been implicated in a wide range of human cancers, including malignant gliomas. Recent studies in glia have demonstrated that activation of Ras can either induce or inhibit proliferation through complex interactions among downstream signaling pathways impinging on cell cycle regulatory proteins. Studies in Schwann cells have begun to delineate the pathways by which Ras regulates the cell cycle in normal and pathological glia, and have identified promising targets for therapeutic intervention in the treatment of PNS and CNS malignant glial tumors.