Significance of nipple enhancement of Paget's disease in contrast enhanced breast MRI
Significance of nipple enhancement of Paget's disease in contrast enhanced breast MRI
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DOI：
10.1007/s00404-009-1244-4
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发表时间：
2010-08-01
影响因子：
2.6
通讯作者：
Seo, Young Jin
中科院分区：
文献类型：
--
作者：
Kim, Hyeon Sook;Seok, Jee Hyun;Seo, Young Jin
为探讨佩吉特病乳头强化在乳腺MRI增强扫描中的意义，收集10例经病理证实的佩吉特病患者。所有10例患者均获得了术前乳房X线片和超声（US），8例患者在术前接受了CE乳腺MRI。回顾性分析了乳腺X线和超声检查结果。在MRI上，对病变侧乳头形态（扁平、不对称或增厚）、强化情况进行对比分析，并对乳腺实质内异常强化病灶进行回顾性分析，10例乳腺X线检查中2例发现乳头形态改变，10例超声检查中6例发现乳头形态改变。MRI上7例可见病变形态改变，8例均可见病变乳头异常强化。10例中7例为DCIS，2例为浸润性导管癌。其余1例患者没有潜在的乳腺实质恶性肿瘤。CE乳腺MRI允许正确检测佩吉特病的乳头受累，即使没有提供临床信息或乳房X线摄影/US结果。
To evaluate significance of nipple enhancement of Paget's disease in contrast enhanced (CE) breast MRI.Ten patients of biopsy proven Paget's disease were included in this study. Preoperative mammogram and ultrasonogram (US) were obtained in all 10 patients, and 8 patients underwent CE breast MRI prior to surgery. Mammographic and US findings were reviewed retrospectively. On MRI, morphology (flattening or asymmetry or thickening) and enhancement of pathologically involved nipple were analyzed comparing with the opposite side, and also reviewed the abnormal enhancing lesion in the breast parenchyma.Morphologic changes of the nipple were detected in 2 out of 10 patients by mammogram and 6 out of 10 patients by US. On MRI, morphologic change was also revealed in 7 patients and abnormal enhancement of involved nipple was observed in all 8 patients. Associated parenchymal enhancing lesions were proved to be DCIS (7 out of 10) and invasive ductal carcinoma (2 out of 10). Remaining one patient had no underlying breast parenchymal malignancy.CE breast MRI allows for the correct detection of nipple involvement of Paget's disease even when clinical information or mammographic/US findings are not provided.